Document Detail

Leigh syndrome: MRI findings in two children.
MedLine Citation:
PMID:  21611066     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Leigh syndrome is a progressive neurodegenerative disorder of childhood. The symmetrical necrotic lesions in the basal ganglia and/or brainstem which appear as hyperintense lesions on T2-weighted MRI is characteristic and one of the essential diagnostic criteria. Recognising this MR imaging pattern in a child with neurological problems should prompt the clinician to investigate for Leigh syndrome. We present here two cases of Leigh syndrome due to different biochemical/genetic defects, and discuss the subtle differences in their MR neuroimaging features.
Al Kartikasalwah; Ngu Lh
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Publication Detail:
Type:  Journal Article     Date:  2010-01-01
Journal Detail:
Title:  Biomedical imaging and intervention journal     Volume:  6     ISSN:  1823-5530     ISO Abbreviation:  Biomed Imaging Interv J     Publication Date:    2010 Jan-Mar
Date Detail:
Created Date:  2011-05-25     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101258681     Medline TA:  Biomed Imaging Interv J     Country:  Malaysia    
Other Details:
Languages:  eng     Pagination:  e6     Citation Subset:  -    
Department of Diagnostic Imaging, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.
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