Document Detail


The Leiden mutation and activated protein C resistance as risk factors for disseminated intravascular coagulation in acutely poisoned patients.
MedLine Citation:
PMID:  16496494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this work was to assess the prevalence of a genetic predisposition to disseminated intravascular coagulation (DIC) among acutely poisoned patients. Activated protein C resistence (APCR) is a genetically determined cause of thrombophilia and DIC development. One hundred seventy-six subjects were divided into three groups: one consisted of 83 acutely poisoned patients with DIC; a second consisted of 57 acutely poisoned patients without DIC; the third group consisted of 91 healthy controls. Abnormal results of APCR testing were found in 24.1% of the poisoned DIC group, 5.3% of the poisoned nonDIC group, and 3.3% of the control group. Genetic tests were performed in 37 selected patients. Factor V Leiden mutation (G/A genotype) was determined to be present in people whose R index value was below 1.9. These results raise the possibility that outcomes of acute poisonings may be influenced by genetic predisposition.
Authors:
Mirosław Prazanowski; Barbara Kur; Małgorzata Barańska; Waldemar Lutz; Bozena Piłacik; Zbigniew Kolaciński
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical toxicology (Philadelphia, Pa.)     Volume:  44     ISSN:  1556-3650     ISO Abbreviation:  Clin Toxicol (Phila)     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-24     Completed Date:  2006-03-14     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101241654     Medline TA:  Clin Toxicol (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  53-7     Citation Subset:  AIM; IM    
Affiliation:
Immunotoxicology Department Nofer Institute of Occupational Medicine in Lodz, Lodz, Poland.
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MeSH Terms
Descriptor/Qualifier:
Activated Protein C Resistance / blood,  genetics*
Acute Disease
Adult
Blood Coagulation Tests
Disseminated Intravascular Coagulation / blood,  genetics*
Factor V / genetics*
Genetic Predisposition to Disease*
Genotype
Humans
Middle Aged
Point Mutation*
Poisoning / blood,  genetics
Prevalence
Risk Factors
Xenobiotics / poisoning*
Chemical
Reg. No./Substance:
0/Xenobiotics; 0/factor V Leiden; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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