Document Detail

Legumains and their functions in plants.
MedLine Citation:
PMID:  12167328     Owner:  NLM     Status:  MEDLINE    
Legumains are a family of plant and animal Asn-specific cysteine proteinases with extra-cytoplasmic localization in vacuoles or cell walls. Plant legumains are involved in Asn-specific propolypeptide processing during, for example, storage-protein deposition in maturing seeds, when these proteins are resistant against degradation by legumains. With the transition to germination and subsequent seedling growth, storage proteins are opened to unlimited cleavage by legumains, which now contribute to protein mobilization. Here, we suggest a hypothesis that unifies both functions of legumains. Their action as propolypeptide-processing or protein-degrading enzymes is naturally controlled by the conformational state of their substrates, which undergo development- or environment-dependent changes. The suggested substrate conformation-dependent differential roles of legumains might not be restricted to seeds but could also apply to cells of different tissues in vegetative organs.
Klaus Müntz; Andrei D Shutov
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in plant science     Volume:  7     ISSN:  1360-1385     ISO Abbreviation:  Trends Plant Sci.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-08     Completed Date:  2002-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9890299     Medline TA:  Trends Plant Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  340-4     Citation Subset:  IM    
Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK), Gatersleben, Germany.
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MeSH Terms
Amino Acid Sequence
Cell Wall / enzymology
Cysteine Endopeptidases / biosynthesis,  classification,  genetics,  metabolism*
Gene Expression Regulation, Plant
Plants / cytology,  enzymology*,  genetics,  metabolism
Protein Conformation
Protein Processing, Post-Translational*
Protein Transport
Seeds / enzymology
Substrate Specificity
Vacuoles / enzymology
Reg. No./Substance:
EC 3.4.22.-/Cysteine Endopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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