| Legacy effects from DCCT and UKPDS: what they mean and implications for future diabetes trials. | |
| | |
MedLine Citation:
|
PMID: 20652839 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The United Kingdom Prospective Diabetes Study (UKPDS) and the Diabetes Chronic Complications Trial (DCCT) are two landmark trials that convincingly demonstrated that tight glycemic control has beneficial effects on microvascular end points. These studies also revealed a "legacy effect," which is a sustained benefit with respect to cardiovascular disease outcomes seen long after the conclusion of the trial. We discuss possible molecular mechanisms that could play a role in causing the legacy effect. |
| | |
Authors:
|
Patrick Murray; Gary W Chune; Vasudevan A Raghavan |
Related Documents
:
|
16037289 - Plasma low-molecular weight fluorescence in type 1 diabetes mellitus. 18752069 - Mass spectrometric quantification of amino acid oxidation products identifies oxidative... 18180609 - Study of factor vii, tissue factor pathway inhibitor and monocyte tissue factor in noni... 18840499 - Diabetic complications: a role for the prorenin-(pro)renin receptor-tgf-beta1 axis? 3407819 - Diabetes in utah among adults: interaction between diabetes and other risk factors for ... 1566219 - Measurement of micro-albuminuria in patients with diabetes mellitus. 2663969 - Hypoglycemic hemiplegia in an adolescent with insulin-dependent diabetes mellitus: a ca... 17963459 - Effects of gatifloxacin and levofloxacin on rates of hypoglycemia and hyperglycemia amo... 14747239 - Left ventricular mass increases with deteriorating glucose tolerance, especially in wom... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current atherosclerosis reports Volume: 12 ISSN: 1534-6242 ISO Abbreviation: Curr Atheroscler Rep Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-09-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: United States |
Other Details:
|
Languages: eng Pagination: 432-9 Citation Subset: IM |
Affiliation:
|
CardioMetabolic and Lipid Clinic Services, Scott and White/Texas A&M Health Sciences Center, Temple, TX, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Irreversible marrow aplasia after single course of 2-chlorodeoxyadenosine for hairy cell leukaemia p...
Next Document: Comorbidities in patients with persistent or chronic immune thrombocytopenia.