| Leg vascular resistance increases during head-up tilt in paraplegics. | |
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MedLine Citation:
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PMID: 15843958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite loss of centrally mediated sympathetic vasoconstriction to the legs, spinal cord-injured individuals cope surprisingly well with an orthostatic challenge. This study assessed changes in leg vascular resistance following head-up tilt in healthy (C) and in paraplegic (P) individuals. After 10 min of supine rest, subjects were tilted 30 degrees head-up. Mean arterial pressure (MAP) and total peripheral resistance (TPR) increased in C (MAP from 76.7 +/ -6.6 mmHg to 80.6 +/- 8.2 mmHg; TPR from 1.12 +/- 0.26 AU to 1.19 +/ -0.31 AU) while both remained unchanged in P. Echo Doppler ultrasound determined red blood cell velocity in the femoral artery, which decreased (P from 18.9+/-6.2 cm/s to 12.5 +/- 4.5 cm/s, P = 0.001; C from 16.3 +/- 6.2 cm/s to 10.8 +/- 5.0 cm/s, P = 0.001) and leg vascular resistance, which increased (P from 402 +/- 137 AU to 643 +/- 274 AU, P = 0.001; C from 238 +/- 68 AU to 400 +/- 122 AU, P = 0.003) from supine to upright. The present study shows that independent of supraspinal sympathetic control, humans are able to increase leg vascular resistance and maintain blood pressure during head-up tilt. |
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Authors:
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Jan T Groothuis; Cécile R L Boot; Sibrand Houtman; Herman van Langen; Maria T E Hopman |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2005-04-21 |
Journal Detail:
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Title: European journal of applied physiology Volume: 94 ISSN: 1439-6319 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-27 Completed Date: 2006-09-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 408-14 Citation Subset: IM |
Affiliation:
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Department of Physiology, University Medical Centre Nijmegen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Female Head Humans Leg / blood supply* Male Paraplegia / physiopathology* Posture* Regional Blood Flow Spinal Cord Injuries / physiopathology Time Factors Vascular Resistance / physiology* |
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