| Leg ulcer and thigh telangiectasia associated with natural killer cell CD56(-) large granular lymphocyte leukemia in a patient with pseudo-Felty syndrome. | |
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MedLine Citation:
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PMID: 19962215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clonal disorders of large granular lymphocytes (LGL) represent a rare spectrum of biologically distinct lymphoproliferative diseases originating either from mature T cells or natural killer cells. Both subtypes can manifest as indolent or aggressive disorders. We report a 77-year-old woman with rheumatoid arthritis, splenomegaly, and neutropenia who developed a painful leg ulcer refractory to treatment and thigh telangiectatic lesions. Because of the association of rheumatoid arthritis, splenomegaly, and nonspecific neutropenia, the diagnosis of Felty syndrome was initially made. Further investigation allowed the diagnosis of a CD56(-) natural killer-cell LGL leukemia and documented skin infiltration by natural killer cells. Cutaneous manifestations of LGL leukemia have been rarely reported. This report of pseudo-Felty syndrome with CD56(-) LGL leukemia, presenting with a leg ulcer and telangiectasia, enhances the role of dermatology in the diagnosis of hematologic neoplasia. |
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Authors:
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Ana Filipa Duarte; Ana Nogueira; Alberto Mota; Teresa Baudrier; Aurea Canelhas; Jorge Cancela; Margarida Lima; Filomena Azevedo |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-12-03 |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 62 ISSN: 1097-6787 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 496-501 Citation Subset: IM |
Copyright Information:
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Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Dermatology and Venereology, Hospital S?o Jo?o, 4200-319 Porto, Portugal. duarte.af.t30@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antigens, CD56 / analysis Arthritis, Rheumatoid / complications Felty's Syndrome / diagnosis, pathology Female Humans Killer Cells, Natural / pathology Leg Ulcer / complications, pathology* Leukemia, Large Granular Lymphocytic / diagnosis, pathology* Neutropenia / pathology Telangiectasis / complications, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD56 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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