| Leg fat mass as measured by dual X-ray absorptiometry (DXA) impacts insulin resistance differently in obese women versus men. | |
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MedLine Citation:
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PMID: 18937100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the association between regional fat mass (FM) and insulin resistance and dyslipidaemia in obese women and men. MATERIAL AND METHODS: Body composition was measured by dual-energy X-ray absorptiometry (DXA) in 109 obese women and 113 obese men. Insulin resistance was measured by (HOMA-IR); insulin sensitivity was estimated by metabolic clearance rate (MCRestOGTT) and insulin secretion by HOMAsecr. Serum lipids were assessed. RESULTS: In women, leg FM was negatively (favourably) associated with HOMA-IR and cholesterol/HDL-cholesterol ratio (p<0.05). Trunk FM was positively (unfavourably) associated with HOMA-IR. Leg/trunk FM ratio was negatively associated with HOMA-IR (p<0.001), cholesterol/HDL-cholesterol ratio (p<0.001) and triglycerides (p<0.01); positively (favourably) with MCRestOGTT (p<0.01) and HDL-cholesterol (p<0.05). No associations were found in men. In women, multiple regression analysis demonstrated that leg/trunk FM ratio was the only explanatory FM for HOMA-IR and MCRestOGTT (R(2) = 0.23 and R(2) = 0.13, respectively; p<0.001), but postmenopausal status was also of importance (R(2) = 0.23, p = 0.019 and R(2) = 0.29, p = 0.015, respectively). CONCLUSIONS: Leg FM has a favourable influence on insulin resistance and dyslipidaemia in obese women, but not demonstrated in this cohort of obese men. |
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Authors:
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Gunnar Aasen; Hans Fagertun; Serena Tonstad; Johan Halse |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 69 ISSN: 1502-7686 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2009-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: Norway |
Other Details:
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Languages: eng Pagination: 181-9 Citation Subset: IM |
Affiliation:
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Spesialistsenteret Pilestredet Park, Pilestredet Park, Oslo, Norway. g.aasen@usa.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon
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methods* Adipose Tissue / radiography* Adult Aged Female Glucose Tolerance Test Humans Insulin Resistance* Leg* Male Middle Aged Obesity / physiopathology, radiography* Postmenopause Premenopause Regression Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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