| Leg heating using far infra-red radiation in patients with chronic heart failure acutely improves the hemodynamics, vascular endothelial function, and oxidative stress. | |
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MedLine Citation:
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PMID: 22975533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Systemic thermal therapy (STT) has been associated with beneficial effects in patients with chronic heart failure (CHF). The fact, however, that it requires a dedicated as well as spacious facility and trained personnel makes it difficult to practice in the daily care of patients with CHF. OBJECTIVE: The aim of this study was to determine whether the leg thermal therapy (LTT) has a positive impact similar to that of STT in patients with CHF. Methods and Results Twenty patients with CHF (57 ± 17 years old, left ventricular ejection fraction=30 ± 10%) received LTT (45°C) for 20 minutes. Immediately after the treatment, the core temperature had increased (+0.3 ± 0.3°C) (p<0.01). While the LTT had no significant effects on the heart rate, systolic arterial pressure, and diastolic blood pressure, it increased the cardiac output (mixed venous oxygen saturation; +2 ± 3%) and decrease the pulmonary capillary wedge pressure (-2 ± 2 mmHg). The LTT significantly improved the flow-mediated vasodilatation (FMD) from 4.8 ± 2.6 to 7.1 ± 3.6%, the antioxidative markers, thiol from 4.0 ± 0.7 to 4.5 ± 0.9 μmoL/g, and the marker of oxidative deoxyribonucleic acid (DNA) damage, urine 8-hydroxy-2'deoxyguanosine (8OHdG) from 100 to 82 ± 3%, respectively (p<0.05). No patient had any adverse effects associated with LTT. Conclusion LTT acutely improved FMD, and oxidative stress in patients with CHF. Although the long-term effect of LTT remains to be investigated, its practicality which is comparable to that of STT would make it an attractive therapeutic strategy for patients with CHF. |
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Authors:
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Shujiro Inoue; Masao Takemoto; Akiko Chishaki; Tomomi Ide; Mari Nishizaka; Mami Miyazono; Hiroyuki Sawatari; Kenji Sunagawa |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2012-09-01 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 51 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-09-14 Completed Date: 2013-04-10 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 2263-70 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Kyushu University Hospital, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antioxidants / metabolism Body Temperature / physiology, radiation effects Cardiac Output / physiology, radiation effects Chronic Disease Endothelium, Vascular / physiopathology, radiation effects* Female Heart Failure / metabolism, physiopathology, therapy* Hemodynamics / physiology, radiation effects* Humans Hyperthermia, Induced / methods* Infrared Rays / therapeutic use* Leg / physiopathology, radiation effects* Male Middle Aged Oxidative Stress / physiology, radiation effects* Pulmonary Wedge Pressure / physiology, radiation effects Vasodilation / physiology, radiation effects |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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