Document Detail

Leg heating using far infra-red radiation in patients with chronic heart failure acutely improves the hemodynamics, vascular endothelial function, and oxidative stress.
MedLine Citation:
PMID:  22975533     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Systemic thermal therapy (STT) has been associated with beneficial effects in patients with chronic heart failure (CHF). The fact, however, that it requires a dedicated as well as spacious facility and trained personnel makes it difficult to practice in the daily care of patients with CHF.
OBJECTIVE: The aim of this study was to determine whether the leg thermal therapy (LTT) has a positive impact similar to that of STT in patients with CHF. Methods and Results Twenty patients with CHF (57 ± 17 years old, left ventricular ejection fraction=30 ± 10%) received LTT (45°C) for 20 minutes. Immediately after the treatment, the core temperature had increased (+0.3 ± 0.3°C) (p<0.01). While the LTT had no significant effects on the heart rate, systolic arterial pressure, and diastolic blood pressure, it increased the cardiac output (mixed venous oxygen saturation; +2 ± 3%) and decrease the pulmonary capillary wedge pressure (-2 ± 2 mmHg). The LTT significantly improved the flow-mediated vasodilatation (FMD) from 4.8 ± 2.6 to 7.1 ± 3.6%, the antioxidative markers, thiol from 4.0 ± 0.7 to 4.5 ± 0.9 μmoL/g, and the marker of oxidative deoxyribonucleic acid (DNA) damage, urine 8-hydroxy-2'deoxyguanosine (8OHdG) from 100 to 82 ± 3%, respectively (p<0.05). No patient had any adverse effects associated with LTT. Conclusion LTT acutely improved FMD, and oxidative stress in patients with CHF. Although the long-term effect of LTT remains to be investigated, its practicality which is comparable to that of STT would make it an attractive therapeutic strategy for patients with CHF.
Shujiro Inoue; Masao Takemoto; Akiko Chishaki; Tomomi Ide; Mari Nishizaka; Mami Miyazono; Hiroyuki Sawatari; Kenji Sunagawa
Related Documents :
1889983 - Shortlasting, unilateral, neuralgiform headache attacks with conjunctival injection, te...
696883 - Alteration in heart rate response to hemorrhage in conscious dogs with volume overload.
632153 - Effects of prostaglandin f2alpha on lung mechanics in nonasthmatic and asthmatic subjects.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  51     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-14     Completed Date:  2013-04-10     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2263-70     Citation Subset:  IM    
Department of Cardiovascular Medicine, Kyushu University Hospital, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antioxidants / metabolism
Body Temperature / physiology,  radiation effects
Cardiac Output / physiology,  radiation effects
Chronic Disease
Endothelium, Vascular / physiopathology,  radiation effects*
Heart Failure / metabolism,  physiopathology,  therapy*
Hemodynamics / physiology,  radiation effects*
Hyperthermia, Induced / methods*
Infrared Rays / therapeutic use*
Leg / physiopathology,  radiation effects*
Middle Aged
Oxidative Stress / physiology,  radiation effects*
Pulmonary Wedge Pressure / physiology,  radiation effects
Vasodilation / physiology,  radiation effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Variation in clinical vitamin D status by DiaSorin liaison and LC-MS/MS in the presence of elevated ...
Next Document:  Red Blood Cell Distribution Width as an Effective Tool for Detecting Fatal Heart Failure in Super-el...