Document Detail


Left hepatectomy versus right hepatectomy for living donor liver transplantation: shifting the risk from the donor to the recipient.
MedLine Citation:
PMID:  23447523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Living donor liver transplantation (LDLT), originally used in children with left lateral segment grafts, has been expanded to adults who require larger grafts to support liver function. Most adult LDLT procedures have been performed with right lobe grafts, and this means a significant risk of morbidity for the donors. To minimize the donor risk for adults, there is renewed interest in smaller left lobe grafts. The smaller graft size increases the recipient risk in the form of small-for-size syndrome (SFSS) and essentially transfers the risk from the donor to the recipient. We review the donor and recipient risks of LDLT and pay particular attention to the different types of liver grafts and the use of graft inflow modification to ameliorate the risk of SFSS. Finally, a new metric is proposed for quantifying the recipient benefit in exchange for a specific donor risk.
Authors:
Garrett R Roll; Justin R Parekh; William F Parker; Mark Siegler; Elizabeth A Pomfret; Nancy L Ascher; John Paul Roberts
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-04-15
Journal Detail:
Title:  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society     Volume:  19     ISSN:  1527-6473     ISO Abbreviation:  Liver Transpl.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-26     Completed Date:  2013-11-13     Revised Date:  2014-04-29    
Medline Journal Info:
Nlm Unique ID:  100909185     Medline TA:  Liver Transpl     Country:  United States    
Other Details:
Languages:  eng     Pagination:  472-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Adult
Hepatectomy / adverse effects,  methods*
Humans
Liver Transplantation / adverse effects*,  mortality
Living Donors*
Morbidity
Risk
Grant Support
ID/Acronym/Agency:
P30 DK026743/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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