Document Detail

Left ventricular hypertrabeculation/noncompaction with and without neuromuscular disorders.
MedLine Citation:
PMID:  15336813     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Left ventricular hypertrabeculation/noncompaction (LVHT) is frequently associated with neuromuscular disorders (NMD). It is unknown, whether LVHT patients differ according to the presence or absence of NMD. Aim of the study was to assess, if clinical, ECG or echocardiographic findings differ between LVHT patients with and without NMD. METHODS: Included were all patients, in whom LVHT was diagnosed between June 1995 and February 2003 in one echocardiographic laboratory. All patients underwent a cardiologic examination and were invited for a neurologic investigation. RESULTS: Of 77 patients with LVHT (19 female, mean age 52 years), 59 were investigated neurologically. Eleven were neurologically normal, 21 had a definite NMD (metabolic myopathy, n=15; Leber's hereditary optic neuropathy, n=3; myotonic dystrophy, n=2 and Becker muscular dystrophy, n=1). The remaining 27 had a NMD of unknown etiology. Neurologically normal patients had more often anginal chest pain than patients with definite NMD (64% vs. 14%, P=0.0042) or NMD of unknown etiology (64% vs. 26%, P=0.0157). Neurologically normal patients were more often in NYHA class 0 or I than patients with NMD of unknown etiology (64% vs. 26%, P=0.0289) and had a thinner interventricular septum than patients with NMD (10.6 mm vs. 12.8 mm, P=0.0253). CONCLUSIONS: Cardiac abnormalities are hardly different between patients with and without NMD.
Claudia Stöllberger; Maria Winkler-Dworak; Gerhard Blazek; Josef Finsterer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  97     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-08-31     Completed Date:  2005-02-03     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  89-92     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Elsevier Ireland Ltd.
2nd Medical Department, Krankenanstalt Rudolfstiftung, Steingasse 31/18, A-1030 Wien, Osterreich, Austria.
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MeSH Terms
Heart Defects, Congenital / complications*,  ultrasonography
Heart Ventricles / abnormalities*
Middle Aged
Neuromuscular Diseases / complications*

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