Document Detail


Left ventricular wall motion response to intravenous propranolol.
MedLine Citation:
PMID:  1132115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of intravenous propranolol on left ventricular wall motion and hemodynamics were studied in 16 patients, 12 with significant coronary artery disease and four with chest pain but no coronary disease. Eight patients received 0.10 mg/kg and eight received 0.15 mg/kg of propranolol intravenously. All underwent atrial pacing at a constant rate. Left ventricular angiograms were performed before and 20 minutes after propranolol. At both doses, propranolol caused no significant change in left ventricular systolic or diastolic pressures, either before or immediately following ventriculography. Cardiac index fell significantly (3.4 plus or minus 0.2 [SEM] to 2.6 plus or minus 0.1 L/min/m-2) with the higher dose only. Of the ten patients with coronary artery disease and adequate ventriculograms, one patient had a normal left ventricle, two had regional hypokinesis, only three had areas of hypokinesis and akinesis, two had dyskinetic and akinetic areas, and two had areas of hypokinesis, akinesis and dyskinesis. No changes in regional contractility occurred with propranolol except for a minimal increase in hypokinesis in one patient at each dosage and equivocal development of a new area of slight hypokinesis in one patient and minimal apex of dyskinesis in another at the higher dosage. Of the four patients without coronary artery disease, two were affected by propranolol, one with initial regional akinesis and dyskinesis had slight worsening with propranolol and one with regional hypokinesis developed a definite new area of hypokinesis. Therefore, propranolol, even in large intravenous doses, resulted in no significant change in left ventricular wall motion in patients with coronary artery disease.
Authors:
S J Shubrooks; L M Zir; R E Dinsmore; J W Harthorne
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  52     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-08-29     Completed Date:  1975-08-29     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  124-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
1-Propanol / pharmacology*
Adult
Angina Pectoris / drug therapy
Angiocardiography
Cineangiography
Coronary Disease / drug therapy*
Dose-Response Relationship, Drug
Female
Heart Catheterization
Heart Ventricles / drug effects*
Hemodynamics / drug effects
Humans
Injections, Intravenous
Male
Middle Aged
Myocardial Contraction / drug effects*
Oxygen Consumption / drug effects
Propranolol / administration & dosage
Tachycardia / drug therapy
Chemical
Reg. No./Substance:
525-66-6/Propranolol; 71-23-8/1-Propanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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