Document Detail

Left ventricular volume determination using Albunex.
MedLine Citation:
PMID:  8679229     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to assess the ability of intravenous injection of Albunex to improve left ventricular volume determination in patients with various cardiac diseases. It is conceivable that the intravenous injection of microbubbles could improve echocardiographic left ventricular border delineation leading to improved interobserver variability. Echocardiograms were obtained during simultaneous intravenous injection of 0.08 and 0.12 ml/kg Albunex (four-chamber view). Within 6 hours after the recording of the contrast echocardiograms routine left heart angiography was performed. Volumes were measured using the slice method in native and contrast echocardiograms as well as in the angiograms by two independent investigators. The mean differences of angiographic-native echocardiographic and angiographic-contrast echocardiographic volumes (ml) as well as the calculated ejection fraction and their confidence intervals were tabulated and significance was anticipated if the confidence interval did not include zero. Significant changes to angiographic values could be observed concerning end-diastolic, echocardiographic, and contrast echocardiographic volumes at end diastole and end systole, while ejection fractions were similar. Differences between observers were significantly smaller in the contrast echocardiographic images than in the native echocardiographic images. Albunex led to a significantly decreased interobserver variability.
R J Zotz; S Genth; A Waaler; R Erbel; J Meyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  9     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:    1996 Jan-Feb
Date Detail:
Created Date:  1996-08-22     Completed Date:  1996-08-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
II Medical Clinic, Johannes Gutenberg University, Mainz, Germany.
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MeSH Terms
Albumins / administration & dosage,  diagnostic use*
Cardiac Volume*
Confidence Intervals
Contrast Media* / administration & dosage
Heart / radiography
Heart Diseases / ultrasonography*
Injections, Intravenous
Middle Aged
Observer Variation
Stroke Volume
Ventricular Function, Left*
Reg. No./Substance:
0/Albumins; 0/Albunex; 0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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