| Left ventricular untwisting rate by speckle tracking echocardiography. | |
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MedLine Citation:
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PMID: 17998458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recent studies validated the measurement of left ventricular (LV) untwisting rate (UR) by speckle tracking echocardiography. A few reports suggest that it may provide additional noninvasive insight into LV diastolic function. METHODS AND RESULTS: Simultaneous echocardiographic imaging and LV pressure measurements (7F Millar catheters) were performed in 8 adult dogs. Loading conditions were altered by caval occlusion, whereas lusitropic state was changed by dobutamine and esmolol infusion. Inferior vena cava occlusion at all experimental stages (baseline, dobutamine, esmolol) led to a significant decrease (P < or = 0.01) in LV end-systolic volume (ESV) and a significant increase in UR (P = 0.03). The best relation was observed between LV UR and ESV (r = -0.8, P < 0.001). The clinical study was conducted in 67 patients (age 57+/-17 years, 19 women) undergoing simultaneous right heart catheterization and echocardiographic imaging, with 20 healthy subjects as a control group. There were 34 patients with ejection fraction (EF) <50% (25+/-9%), and 33 patients with normal EF and diastolic dysfunction (64+/-7%). Patients with LV systolic dysfunction had a significantly lower UR (-55 omicron/s) in comparison with the control group (-89 omicron/s) and patients with normal EF (-104 omicron/s, P < 0.05), and the determinants of LV UR were twist, ESV, and tau (r2 = 0.83, P < 0.001). In patients with diastolic dysfunction and normal EF, twist and ESV were the independent predictors (r2 = 0.71, P < 0.001). CONCLUSIONS: LV UR is reduced in patients with depressed EF, but not in those with diastolic dysfunction and normal EF, and is primarily determined by twist and ESV. |
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Authors:
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Jianwen Wang; Dirar S Khoury; Yong Yue; Guillermo Torre-Amione; Sherif F Nagueh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-12 |
Journal Detail:
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Title: Circulation Volume: 116 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-27 Completed Date: 2008-01-29 Revised Date: 2008-07-08 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 2580-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, The Methodist DeBakey Heart Center, The Methodist Hospital, Houston, Tex 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Case-Control Studies Dogs Echocardiography / methods* Female Heart Failure, Diastolic Humans Male Middle Aged Stroke Volume* Ventricular Dysfunction, Left / pathology* Ventricular Pressure |
| Comments/Corrections | |
Comment In:
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Circulation. 2008 May 13;117(19):e336; author reply e337
[PMID:
18474819
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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