| Left-ventricular unloading with a new pulsatile assist device: the HIA-VAD system and its influence on myocardial stunning. | |
| | |
MedLine Citation:
|
PMID: 8775855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To assess the mechanical unloading properties of a new pneumatic cardiac assist device (60 ml Medos HIA-VAD) and its possible influence on recovery from myocardial stunning we performed a study in 12 anaesthetized sheep. After left thoracotomy measuring transducers were placed and the assist device connected between the left-atrial appendage and the descending thoracic aorta. Global hemodynamics were measured before and after unloading was performed. Myocardial stunning was induced by transient occlusion of a coronary artery for 15 minutes and regional myocardial wall thickening was measured. A group without unloading served as controls (group I, n = 4). In a second group unloading was performed during the last ten minutes of ischemia (group II, n = 4) and in a third group unloading was performed for 30 minutes starting after ten minutes of reperfusion (group III, n = 4). After starting the Medos HIA-VAD, significant unloading could be demonstrated: left-ventricular dP/dtmax decreased significantly (p < 0.05) to 54% and 61% in groups II and III and left-atrial pressure to 50% and 71%, respectively. Systolic and mean arterial pressure did not change significantly (p > 0.05), while the diastolic pressure increased (p < 0.05) to 134% and 138% in groups II and III. After mechanical unloading whether during ischemia or during reperfusion systolic wall thickening in the postischemic area recovered to 103% and 92% of preischemic control in groups II and III, respectively. Recovery was incomplete in the non-unloaded controls (76%) (p < 0.05 versus groups II and III). Post-ejection thickening, a diastolic measure of stunning, diminished significantly after unloading in both protocols (p < 0.05 for groups II and III versus group I). We conclude that mechanical unloading with the 60 ml Medos HIA-VAD significantly improves recovery from myocardial stunning. |
| | |
Authors:
|
F R Waldenberger; E Pongo; B Meyns; W Flameng |
Related Documents
:
|
10198715 - In vivo evaluation of the national cardiovascular center electrohydraulic total artific... 16174125 - Three-dimensional echocardiographic assessment of a patient supported by intravascular ... 12555165 - Reversal mechanisms of left ventricular remodeling: lessons from left ventricular assis... 11847595 - Sutured coronary artery grafting utilizing the heartflo anastomosis device--first clini... 3594775 - Effects of heart rate on ventricular size, stroke volume, and output in the normal huma... 16291445 - Wide-complex tachycardia: beyond the traditional differential diagnosis of ventricular ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Thoracic and cardiovascular surgeon Volume: 43 ISSN: 0171-6425 ISO Abbreviation: Thorac Cardiovasc Surg Publication Date: 1995 Dec |
Date Detail:
|
Created Date: 1996-12-16 Completed Date: 1996-12-16 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7903387 Medline TA: Thorac Cardiovasc Surg Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 313-9 Citation Subset: IM; S |
Affiliation:
|
Department of Cardiac Surgery and Centre for Experimental Surgery and Anesthesiology, Katholieke Universiteit, Leuven, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biomechanics Evaluation Studies as Topic Female Heart-Assist Devices* Hemodynamics Myocardial Reperfusion Injury / prevention & control Myocardial Stunning / pathology, physiopathology*, therapy Myocardium / pathology Sheep |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Embryological observations on the morphogenesis of double-outlet right ventricle with subaortic vent...
Next Document: Comparison of the early results of coronary artery bypass grafting with and without extracorporeal c...