Document Detail

Left ventricular twist mechanics in a canine model of reversible congestive heart failure: a pilot study.
MedLine Citation:
PMID:  19131008     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Left ventricular (LV) twist dynamics play an important role in LV systolic and diastolic function. The aim of this preliminary study was to investigate LV twist dynamics in a canine model of reversible congestive heart failure (CHF). METHODS: Pacing systems were implanted in adult dogs, and continuous chronic right ventricular pacing (230-250 beats/min) was applied until CHF induction. Pacing was then stopped to allow the heart to recover. Echocardiography and LV catheterization were performed at baseline, during CHF while pacing was temporarily switched off, and during recovery. LV twist was computed as the difference between apical and basal rotation measured using 2-dimensional speckle tracking. Torsion was further calculated as LV twist divided by the LV long axis. The untwisting rate was computed as the peak diastolic time derivative of twist. RESULTS: In 6 dogs that completed the study, we found that CHF developed after 2 to 4 weeks of pacing, with LV end-diastolic volume, end-systolic volume, end-diastolic pressure, and the time constant of relaxation during isovolumic relaxation period (tau) all increasing significantly compared with baseline and recovering to normal levels 2 to 4 weeks after pacing was stopped. LV twist, torsion, and untwisting rate decreased significantly with CHF compared with baseline and improved during recovery from CHF. CONCLUSION: LV twist dynamics reflect pacing-induced CHF and its reversal as assessed by echocardiographic speckle tracking.
Jianwen Wang; Sherif F Nagueh; Nilesh S Mathuria; Hue-Teh Shih; Dorin Panescu; Dirar S Khoury
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  22     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-03-26     Revised Date:  2010-09-22    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
Department of Cardiology, Methodist DeBakey Heart and Vascular Center, The Methodist Hospital Research Institute, Houston, TX 77030, USA.
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MeSH Terms
Heart Failure / physiopathology*,  ultrasonography*
Heart Ventricles / physiopathology*,  ultrasonography*
Myocardial Contraction*
Pilot Projects
Torsion, Mechanical
Ventricular Dysfunction, Left / physiopathology*,  ultrasonography*
Grant Support
R01 HL068768/HL/NHLBI NIH HHS; R01 HL068768-06/HL/NHLBI NIH HHS; R01 HL068768-07/HL/NHLBI NIH HHS; R01 HL068768-08/HL/NHLBI NIH HHS

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