| Left ventricular thrombi after short-term high-dose anticoagulants in acute myocardial infarction. | |
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MedLine Citation:
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PMID: 3665957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the effect of short-term, high-dose anticoagulation on the subsequent occurrence of left ventricular (LV) thrombi after a first anterior wall acute myocardial infarction (AMI), 21 patients received placebo and 21 high-dose anticoagulants during the first 10 days of the acute infarction. They were studied with cross-sectional echocardiography 10 days and 1.3 and 6 months post infarction. At 1 month, 6 of 7 thrombi present in the placebo group at 10 days were still visible. No thrombi were detected at 10 days in the anticoagulation group, but 6 patients had developed a LV thrombus at 1 month. These 12 patients with LV thrombi were subsequently treated with oral warfarin for 2 months, after which all thrombi had disappeared. Warfarin was then discontinued, and a thrombus had recurred in 5 patients after 6 months. Apical akinesis at 10 days was a predictor for thrombus with a sensitivity and specificity of 100% and 72.2%, respectively. Three of the 13 patients with LV thrombi suffered stroke in contrast to none without thrombi (P = 0.025). We conclude that after discontinuation of short-term high-dose anticoagulation therapy in anterior AMI, LV thrombi may develop rapidly and lead to embolic complications, particularly in patients with persisting apical akinesis. |
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Authors:
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K A Johannessen; J E Nordrehaug; G von der Lippe |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: European heart journal Volume: 8 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1987 Sep |
Date Detail:
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Created Date: 1987-12-15 Completed Date: 1987-12-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 975-80 Citation Subset: IM |
Affiliation:
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Medical Department, Diakonissehjemmet Hospital, Bergen, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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therapeutic use* Echocardiography Heart Diseases / etiology*, prevention & control Humans Myocardial Infarction / complications*, drug therapy Prospective Studies Random Allocation Thrombosis / etiology*, prevention & control Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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