Document Detail

Left ventricular systolic function of newborns with asphyxia evaluated by tissue Doppler imaging.
MedLine Citation:
PMID:  19340476     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to evaluate the left ventricular systolic function of newborns with asphyxia using tissue Doppler imaging (TDI). Newborns with a history of asphyxia were divided into severe and mild groups based on their Apgar scores; normal newborns without asphyxia served as the controls. Left ventricular ejection fraction (LVEF), fraction shortening (FS), and stroke volume (SV) were measured by M-mode echocardiography at 24, 48, and 72 h after birth. The peak systolic velocity of the anterior mitral valve leaflet (Sm wave) was measured with TDI. Cardiac troponin I (CTnI) was measured. The results revealed that the LVEF and FS of the severe asphyxia group at 24 h were significantly lower than those at later time points (P < 0.01). These parameters were also significantly lower than those of the mild and control groups (P < 0.01). SV was not significantly different among the three groups. Sm wave of asphyxia groups was significantly lower than that of control group (P < 0.001). In the severe asphyxia group, Sm wave at 24 h was significantly lower than that at 48 or 72 h (P < 0.001). CTnI values of the severe asphyxia group were remarkably higher than those of the other two groups (P < 0.01). The findings of this study indicate decreased left ventricular systolic function of newborn children after asphyxia. Sm by TDI is a more sensitive indicator of left ventricular systolic function than LVEF, FS, or SV by M-mode echocardiography.
Yi Wei; JianXin Xu; Ting Xu; Jing Fan; ShaoYing Tao
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-02
Journal Detail:
Title:  Pediatric cardiology     Volume:  30     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  741-6     Citation Subset:  IM    
Department of Pediatrics, Jin Hua Municipal Central Hospital, Jin Hua, Zhejiang 321000, China.
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MeSH Terms
Asphyxia Neonatorum / blood,  physiopathology*,  ultrasonography
Echocardiography, Doppler, Color / methods*
Follow-Up Studies
Heart Ventricles / physiopathology,  ultrasonography*
Infant, Newborn
Myocardium / metabolism
Retrospective Studies
Severity of Illness Index
Stroke Volume / physiology*
Troponin I / blood
Ventricular Function, Left / physiology*
Reg. No./Substance:
0/Troponin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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