Document Detail


Left ventricular structure and function in obese adolescents: relations to cardiovascular fitness, percent body fat, and visceral adiposity, and effects of physical training.
MedLine Citation:
PMID:  11986479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Little is known about the relations of fitness and fatness to left ventricular structure and function in obese adolescents. This project had 2 purposes: 1) to determine the correlations of cardiovascular fitness and adiposity to left ventricular parameters in obese adolescents; and 2) to see the effect of 8 months of physical training (PT) at low and high intensities. DESIGN: Obese 13- to 16-year-olds (N = 81) were tested at baseline and then randomly assigned to lifestyle education (LSE) alone, LSE plus moderate-intensity PT, or LSE plus high-intensity PT. Follow-up testing was conducted 8 months later. Because no significant differences were found between moderate-intensity and high-intensity PT, the groups were combined to form a LSE + PT group. INTERVENTION: Eight months of PT, offered 5 days per week with the target energy expenditure for all PT participants being 250 kcal/session, and LSE every 2 weeks. Outcome Measures. Left ventricular mass divided by height to the 2.7th power (LVM/Ht(2.7)), midwall fractional shortening (MFS), and relative wall thickness (RWT) were measured using M-mode echocardiography. Cardiovascular fitness was measured by a maximal multistage treadmill test; percent body fat (%BF) with dual-energy radiograph absorptiometry; and visceral adipose tissue (VAT) with magnetic resonance imaging. RESULTS: At baseline, high levels of VAT were associated with higher RWT (r = 0.30) and lesser MFS (r = -0.29). Compared with the LSE-alone group, the LSE + PT group significantly improved in cardiovascular fitness and decreased in %BF and VAT. However, there were no significant differences between groups on changes in LVM/Ht(2.7), MFS, or RWT. Individual changes in cardiovascular fitness, %BF, and VAT did not correlate significantly with interindividual changes in left ventricular structure and function. CONCLUSIONS: High levels of VAT were associated with unfavorable left ventricular structure and function. However, no evidence was provided that an 8-month PT program, which improved cardiovascular fitness and reduced general and visceral adiposity, improved left ventricular structure and function. Future studies consisting of longer training programs and/or greater weight reductions are needed to see whether the adverse left ventricular effects of obesity can be ameliorated by exercise training.
Authors:
Brett M Mitchell; Bernard Gutin; Gaston Kapuku; Paule Barbeau; Matthew C Humphries; Scott Owens; Sarita Vemulapalli; Jerry Allison
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  109     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-02     Completed Date:  2002-05-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E73-3     Citation Subset:  AIM; IM    
Affiliation:
Georgia Prevention Institute, Department of Pediatrics, Augusta, Georgia 30912, USA. brettmitchell@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / anatomy & histology*
Adolescent
Age Factors
Body Constitution / physiology
Exercise Therapy / methods*
Female
Health Education / methods
Heart Ventricles / anatomy & histology*
Humans
Life Style
Magnetic Resonance Imaging / statistics & numerical data
Male
Obesity / diagnosis*,  therapy*
Physical Fitness / physiology*
Ventricular Function
Ventricular Function, Left* / physiology
Weight Loss / physiology
Grant Support
ID/Acronym/Agency:
HL55564/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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