Document Detail

Left ventricular structure and diastolic function in subjects with two hypertensive parents.
MedLine Citation:
PMID:  11800056     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To examine the influence of (i) strong predisposition to essential hypertension and (ii) insulin sensitivity and plasma levels of cardiomyotrophic hormones on echocardiographic parameters of left ventricular structure and function. METHODS: 26 normotensive subjects (age 18-35) with bi-parental hypertension and 26 matched controls with normotensive parents. Families with non-insulin-dependent diabetes or morbid obesity were excluded. (i) Echocardiography; (ii) plasma concentrations of renin, angiotensin-II, aldosterone, epinephrine and norepinephrine; (iii) euglycaemic, hyperinsulinemic clamp study. RESULTS (means +/- SD): Hypertension-prone subjects vs controls had (i) higher resting systolic (117.0 +/- 14.0 vs 107.1 +/- 11.9 mmHg), and 24-h diastolic blood pressure (77.9 +/- 7.1 vs 72.9 +/- 7.2 mmHg), (ii) higher relative wall thickness (RWT) (0.39 +/- 0.09 vs 0.34 +/- 0.06). They had similar left vetricular mass index, diastolic function parameters, insulin sensitivity and plasma concentrations of cardiomyotrophic hormones. The increased RWT was not attributable to any other factor than the systolic blood pressure. CONCLUSION: In a carefully selected group of subjects with two hypertensive parents compared to a control group, the only echocardiographic change demonstrated was an increased RWT. This remodelling was attributable to a higher systolic blood pressure in the hypertension-prone subjects, but not to insulin sensitivity or a selection of cardiomyotrophic hormones.
U B Andersen; F Steensgaard-Hansen; J Rokkedal; H Ibsen; H Dige-Petersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure     Volume:  10     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-21     Completed Date:  2003-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Denmark.
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MeSH Terms
Aldosterone / blood,  physiology
Angiotensin II / blood,  physiology
Blood Pressure
Case-Control Studies
Catecholamines / blood,  physiology
Family Health
Hypertension / blood,  etiology*
Insulin Resistance / physiology
Renin / blood,  physiology
Ventricular Dysfunction, Left / blood,  etiology*
Ventricular Remodeling / physiology*
Reg. No./Substance:
0/Catecholamines; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; EC

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