Document Detail


Left ventricular structural and functional changes in the metabolic syndrome.
MedLine Citation:
PMID:  19614794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To test the hypothesis that the cardiac structural and functional abnormalities of the metabolic syndrome (MS) are independent of body mass index (BMI), 160 untreated patients (aged 47+/-1 years [mean +/- SEM], 53% male) underwent 2-dimensional echocardiography and tissue Doppler imaging and evaluation for MS. Participants with MS and controls were similar in age, BMI, and ejection fraction, but those with MS had greater left ventricular relative wall thickness (RWT) (0.43+/-0.008 vs 0.39+/-0.005, P<.001), reduced midwall fractional shortening (MFS) (13%+/-0.3% vs 14.2%+/-0.3%, P<.05), and reduced peak mitral annular velocity (Em) (9.9+/-0.5 vs 12.3+/-0.5 cm/sec, P<.01) than controls. There was a linear relationship between the number of features of MS and Em velocity (P<.001), RWT (P<.001), and MFS (P<.05). In a stepwise multiple regression analysis adjusting for likely determinants, MS was an independent predictor of Em in addition to age and nonindexed left ventricular mass. MS is associated with left ventricular concentric remodeling and reduced systolic and diastolic function independent of BMI.
Authors:
Azra Mahmud; Ibrahim Almuntaser; Angie Brown; Gerard King; Peter Crean; John Feely
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the cardiometabolic syndrome     Volume:  4     ISSN:  1559-4572     ISO Abbreviation:  -     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101284690     Medline TA:  J Cardiometab Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Therapeutics and Hypertension Clinic, Trinity College and St. James's Hospital, Dublin, Ireland. mahmuda@tcd.ie
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Blood Pressure
Body Mass Index*
Case-Control Studies
Cross-Sectional Studies
Echocardiography, Doppler
Female
Humans
Male
Metabolic Syndrome X / complications*,  physiopathology,  ultrasonography
Middle Aged
Myocardial Contraction*
Regression Analysis
Risk Assessment
Risk Factors
Ventricular Dysfunction, Left / etiology*,  physiopathology,  ultrasonography
Ventricular Remodeling*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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