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Left ventricular sphericity index predicts systolic dysfunction in rats with experimental aortic regurgitation.
MedLine Citation:
PMID:  24699853     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Although an increased left ventricular (LV) diastolic diameter (DD) and a decreased ejection fraction (EF) have been used as markers for the surgical replacement of an insufficient aortic valve, these signals may be observed when irreversible myocardium damage has already occurred. The aim of this study was to determine whether change in LV geometry predicts systolic dysfunction in experimental aortic regurgitation. Methods: Male Wistar rats underwent surgical acute aorta regurgitation (AR group, n= 23) or a sham operation (SH group, n= 12). After the procedure, serial transthoracic echocardiograms were performed at 1, 4, 8 and 16 weeks. At the end of protocol, the LV, lungs and liver were dissected and weighed. Results: During the follow-up, no animal developed overt heart failure. There was a correlation between the LV sphericity index (SI) and reduced fractional shortening (FS, p<0.001) over time. A multiple regression model showed that the LVDD-SI association at 8 weeks was a better predictor of decreased FS at week 16 (R(2)=0.50; p<0.001) than was the LVDD alone (R(2)= 0.39; p=0.001). Conclusions: LV geometry associated with increased LVDD improved the prediction of systolic dysfunction in experimental aortic regurgitation.
Authors:
Meliza G Roscani; Bertha Fulan Polegato; Suzana Et Minamoto; Ana Paula M Lousada; Marcos Ferreira Minicucci; Paula Azevedo; Luiz Shiguero Matsubara; Beatriz Bojikian Matsubara
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-3
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  -     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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