Document Detail


Left ventricular size and function after subcutaneous administration of terbutaline.
MedLine Citation:
PMID:  7226928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the response of the left ventricle to subcutaneously administered terbutaline sulfate, a proposed beta-2 selective agonist, we evaluated 12 patients who had suffered previous myocardial infarctions using equilibrium radionuclide angiography. Six patients (group 1) had normal global left ventricular ejection fraction at rest less than 0.49). All patients had a marked decline in end-diastolic volume and end-systolic volume with a significant (P less than 0.01) increase in ejection fraction after terbutaline injection. Cardiac output increased 30 percent in group 2 patients because of an increase in stroke volume, with little change in heart rate (plus or minus 3.1 beats per minute, P equals NS). Cardiac output increased 7 percent in the patients in groups 1, due primarily to an increase in heart rate in 7 beats per minute (+9 percent) with little change in stoke volume. Systemic vascular resistance decreased significantly more in the patients with compensated heart failure than the subjects in group 1 (342 plus or minus 84 vs 90 plus or minus 35 dynes-sec cm(-5), P less than 0.05). We conclude that terbutaline exerts its most beneficial effect on the left ventricle in patients with depressed resting global function, and may prove to be a useful agent in the treatment of congestive heart failure.
Authors:
R Slutsky; W Hooper; K Gerber; W Ashburn; G Curtis; J Karliner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  79     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-07-23     Completed Date:  1981-07-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  501-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Pressure / drug effects
Heart Rate / drug effects
Heart Ventricles / physiopathology*,  radionuclide imaging
Hemodynamics / drug effects*
Humans
Injections, Subcutaneous
Male
Middle Aged
Myocardial Infarction / drug therapy*,  physiopathology,  radionuclide imaging
Terbutaline / administration & dosage,  therapeutic use*
Grant Support
ID/Acronym/Agency:
HL-17682/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
23031-25-6/Terbutaline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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