Document Detail

Left ventricular rupture after double valve replacement in a patient with myocarditis due to myasthenia gravis : case report.
MedLine Citation:
PMID:  25006617     Owner:  NLM     Status:  MEDLINE    
Myasthenia gravis is an autoimmune disease characterised by a weakness of the skeletal muscles, with remissions and exacerbations due to antibodies acting on the acetylcholine receptors. This leads to the characteristic defect transmission in the neuromuscular junction. Treatment includes anticholinesterase agents, thymectomy, and immunosuppression. Surgical thymectomy can induce remission or improvement, allowing for reduction in the immunosuppressive treatment. The case of an 84-year-old female patient with myasthenia gravis, aortic valve stenosis, mitral valve regurgitation and myocarditis is described. The development of myocarditis was related to inflammatory cell infiltration, and progressive and additive focal cellular necrosis associated with reactive myocardial fibrosis. After replacement of the mitral valve, complications arose whereby a rupture of the left ventricular posterior wall occurred, which caused massive bleeding and sudden death on the operating table.
Mihalis Argiriou; Vasilis Patris; Niki Lama; Sotirios Katsaridis; Orestis Argiriou; Christos Charitos
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cardiovascular journal of Africa     Volume:  24     ISSN:  1680-0745     ISO Abbreviation:  Cardiovasc J Afr     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-12-30     Completed Date:  2014-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101313864     Medline TA:  Cardiovasc J Afr     Country:  South Africa    
Other Details:
Languages:  eng     Pagination:  e5-7     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Aortic Valve Stenosis / complications,  diagnosis,  surgery*
Blood Loss, Surgical
Fatal Outcome
Heart Rupture / etiology*
Heart Valve Prosthesis Implantation / adverse effects*
Mitral Valve Insufficiency / complications,  diagnosis,  surgery*
Myasthenia Gravis / complications*
Myocarditis / diagnosis,  etiology*
Myocardium / pathology
Patient Selection
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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