| Left ventricular remodelling in patients with moderate systolic dysfunction after myocardial infarction: favourable effects of exercise training and predictive role of N-terminal pro-brain natriuretic peptide. | |
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MedLine Citation:
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PMID: 18277196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To investigate the effects of exercise training (ET) on left ventricular (LV) volumes, cardiopulmonary functional capacity and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in postinfarction patients with moderate LV dysfunction. METHODS: Sixty-one postinfarction patients were randomized into two groups: group T [n=30, LV ejection fraction (EF) 41.6+/-11.3%, mean+/-SD] entered a 6-month ET programme, whereas group C (n=31, EF 42.0+/-7.6%, P=NS) did not. NT-proBNP assay, Doppler-echocardiography and cardiopulmonary exercise test were performed upon enrolment and at sixth months. RESULTS: At sixth months, trained patients showed an improvement in workload (+26%, P<0.001), Vo2peak (+31%, P<0.001), LV end-diastolic volume index (LVEDVI; -9%, P<0.001), a reduction in NT-proBNP (-71%, P<0.001) and a significant correlation between changes in NT-proBNP and in LVEDVI (r=0.858, P<0.001). Baseline NT-proBNP correlated with changes in LVEDVI in both trained (r=0.673, P<0.001) and untrained (r=0.623, P<0.001) patients. Group C showed unfavourable LVEDVI dilation (+8%, P<0.001; T vs. C group, P<0.001) and a smaller reduction in NT-proBNP (-40%, P<0.001; T vs. C group, P<0.001). CONCLUSIONS: Six month ET induced a favourable LV remodelling and a marked fall in NT-proBNP that could predict LV remodelling in postinfarction patients with moderate LV dysfunction. |
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Authors:
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Francesco Giallauria; Plinio Cirillo; Rosa Lucci; Mario Pacileo; Anna De Lorenzo; Mariantonietta D'Agostino; Sabino Moschella; Marianna Psaroudaki; Domenico Del Forno; Francesco Orio; Dino Franco Vitale; Massimo Chiariello; Carlo Vigorito |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 15 ISSN: 1741-8267 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-15 Completed Date: 2008-06-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 113-8 Citation Subset: IM |
Affiliation:
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Cardiac Rehabilitation Unit , Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Naples, Italy. giallauria@libero.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Echocardiography, Doppler Exercise Test Exercise Therapy* Female Humans Linear Models Male Middle Aged Myocardial Infarction / blood, rehabilitation* Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Predictive Value of Tests Prospective Studies Questionnaires Systole Treatment Outcome Ventricular Dysfunction, Left / blood, rehabilitation* Ventricular Remodeling |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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