Document Detail

Left ventricular pump function in renal hypertensive dogs with cardiac hypertrophy.
MedLine Citation:
PMID:  2947477     Owner:  NLM     Status:  MEDLINE    
We compared open-chest left ventricular (LV) pump performance after autonomic blockade under controlled loading conditions in normal dogs and in dogs where chronic renovascular hypertension had produced moderate concentric LV hypertrophy (LVH). Mean LV pressure (MLVP) provided a measure of ventricular load independent of vascular properties. We found an inverse relationship between MLVP and cardiac index (CI) in both groups when peripheral resistance was altered at constant left atrial pressure. However, CI declined significantly less in LVH hearts as MLVP was increased. The slope of the linear MLVP-CI plot (LV source resistance) was 1.91 times the value observed in normal dogs. LVH hearts developed more steady-flow external power than their normal counterparts, and the power optimum was reached at a much higher mean arterial pressure. Isovolumic maximum rate of LVP rise was 1.28 times higher in LVH than normal dogs (P less than 0.01) in proportion to the increase in wall thickness. Our results suggest that additional muscle with normal contractile properties and greater emptying due to the increased wall-to-lumen ratio accounted for the increased pump performance in LVH.
A Broughton; P I Korner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  251     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-01-22     Completed Date:  1987-01-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1260-6     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output
Cardiomegaly / complications,  physiopathology*
Heart / physiopathology*
Heart Ventricles / physiopathology
Hypertension, Renal / complications,  physiopathology*
Nitroprusside / pharmacology
Organ Size
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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