Document Detail

Left ventricular performance during propofol or methohexital anesthesia: isotopic and invasive cardiac monitoring.
MedLine Citation:
PMID:  1858989     Owner:  NLM     Status:  MEDLINE    
Using gated radionuclide ventriculography and invasive cardiac monitoring, the effects of propofol and methohexital on left ventricular volumes and function were investigated in 22 unpremedicated patients (ASA physical status III, 50-78 yr) with chronic coronary artery disease (NYHA class II-III). Anesthesia was induced with either propofol or methohexital (2 mg/kg), followed by a maintenance infusion of 100 Vecuronium (0.05 mg/kg) was administered and ventilation (FIO2, 1.0) was manually controlled (FECO2, 0.04-0.05). Data acquisitions were serially obtained over 15 min. Propofol and methohexital anesthesia caused an average 15% decrease in mean arterial pressure, associated with a 20% decrease in cardiac index without a decrease in systemic vascular resistance index. It is interesting that the determinants of these hemodynamic effects were different. Heart rate did not change during propofol infusion despite the decrease in mean arterial pressure, whereas heart rate increased during methohexital infusion. In the propofol group, the decrease in cardiac index was associated with decreases in indicators of preload (end-diastolic volume and pulmonary capillary wedge pressure), whereas end-systolic volume and global ejection fraction did not change statistically. In the methohexital group, the decrease in cardiac index was associated with a decrease in global ejection fraction and an increase in end-systolic volume, whereas indicators of preload remained unchanged. It is concluded that methohexital reduces left ventricular performance. In contrast, propofol preserves left ventricular performance despite a likely negative inotropic effect.
J Y Lepage; M L Pinaud; J H Helias; A Y Cozian; Y Le Normand; R J Souron
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  73     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-29     Completed Date:  1991-08-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  AIM; IM    
Département d'Anesthésie-Réanimation Chirurgicale, Centre Hospitalier Régional et Universitaire, Nantes, France.
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MeSH Terms
Anesthesia, Intravenous*
Coronary Disease / complications*
Gated Blood-Pool Imaging
Hemodynamics / drug effects
Middle Aged
Monitoring, Intraoperative
Urologic Diseases / surgery
Ventricular Function, Left / drug effects*
Reg. No./Substance:
18652-93-2/Methohexital; 2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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