| Left ventricular morphology and function in patients with atherosclerotic renovascular disease. | |
| | |
MedLine Citation:
|
PMID: 16049071 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Atherosclerotic renovascular disease (ARVD) is associated with heart disease. There has been no systematic study of cardiac structure and function in patients with this condition. In this study, the epidemiology of cardiac changes and their relationship to renal function, renovascular anatomy, and BP are delineated. With the use of a cross-sectional design, 79 patients with ARVD and 50 control patients without ARVD underwent echocardiography and 24-h ambulatory BP monitoring. Clinical and biochemical data were collected. Results were analyzed according to renal function, residual renal artery patency, and unilateral or bilateral ARVD. Only 4 (5.1%) patients with ARVD had normal cardiac structure and function. Patients with ARVD (age 70.7 +/- 7.5 yr; estimated GFR 36 +/- 19 ml/min) had significantly more cardiovascular comorbidity (77.2 versus 42.0%; P < 0.001), greater prevalence of left ventricular (LV) hypertrophy (78.5 versus 46.0%; P < 0.001) and LV diastolic dysfunction (74.6 versus 40.0%; P < 0.001), and greater LV mass index (183 +/- 74 versus 116 +/- 33 g/m2; P < 0.001) and LV end-diastolic volume index (82 +/- 35 versus 34 +/- 16 ml/m2; P < 0.001) than control subjects. BP was similar for both patient groups. For patients with ARVD, neither renal function nor renal artery patency predicted a difference in echocardiographic or ambulatory BP monitoring parameters. Patients with bilateral ARVD had greater LV mass index and LV dilation than patients with unilateral disease. Patients with ARVD exhibit a high prevalence of cardiac morphologic and functional abnormalities at early stages of renal dysfunction. Such patients must be identified early in their disease course to allow risk factor modification. |
| | |
Authors:
|
Julian R Wright; Ala'a E Shurrab; Anne Cooper; Paul R Kalra; Robert N Foley; Philip A Kalra |
Publication Detail:
|
Type: Journal Article Date: 2005-07-27 |
Journal Detail:
|
Title: Journal of the American Society of Nephrology : JASN Volume: 16 ISSN: 1046-6673 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 2005 Sep |
Date Detail:
|
Created Date: 2005-08-26 Completed Date: 2006-01-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: United States |
Other Details:
|
Languages: eng Pagination: 2746-53 Citation Subset: IM |
Affiliation:
|
Department of Nephrology, Hope Hospital, Salford, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Atherosclerosis / complications*, pathology, physiopathology Blood Pressure Monitoring, Ambulatory Case-Control Studies Cross-Sectional Studies Echocardiography Female Humans Hypertension, Renovascular / complications, pathology, physiopathology Hypertrophy, Left Ventricular / etiology*, pathology Kidney Diseases / complications*, pathology, physiopathology Male Middle Aged Renal Artery / pathology, radiography Ventricular Dysfunction, Left / etiology*, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Developmental antecedents of cardiovascular disease: a historical perspective.
Next Document: Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-ba...