| Left ventricular mechanical synchrony from stress and rest (82)Rb PET myocardial perfusion ECG-gated studies: Differentiating normal from LBBB patients. | |
| | |
MedLine Citation:
|
PMID: 21927978 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: We have previously reported normal values for LV mechanical synchrony from post-stress exercise (99m)Tc SPECT studies; the goal of this study was to develop normal values for mechanical synchrony from pharmacologic stress and rest (82)Rb PET studies and compare these values to a population of LBBB patients. METHODS AND RESULTS: The normal population consisted of 40 patients with a low likelihood of coronary artery disease. The LBBB population consisted of 23 patients with ECG evidence of LBBB. All patients were imaged with pharmacologic stress and processed using SyncTool™ (Emory Cardiac Toolbox™). Means and standard deviations were calculated for the stress and rest phase parameters. Normal male and female phase standard deviation were 15.0 ± 7.0 and 13.2 ± 7.7, respectively, for stress (P = NS), and 22.7 ± 13.2 and 16.6 ± 14.3 for rest (P = NS). Normal male and female histogram bandwidth were 38.1 ± 13.3 and 32.0 ± 13.5, respectively, for stress (P = NS) and 50.8 ± 18.7 and 44.4 ± 44.9 for rest (P = NS). ROC analysis yielded a sensitivity/specificity as high as 80%/90% for males, and 92%/75% for females (P = NS). CONCLUSIONS: Normal values for LV mechanical synchrony have been developed for (82)Rb pharmacologic stress and rest PET studies; furthermore, the stress pharmacologic values do not differ significantly from our previously reported exercise post-stress SPECT normal values. Finally, ROC analysis confirmed that these normal values were able to differentiate normal and LBBB populations. |
| | |
Authors:
|
C David Cooke; Fabio P Esteves; Ji Chen; Ernest V Garcia |
Related Documents
:
|
10482738 - Prediction and compensation by an internal model for back forces during finger opening ... 12127838 - Increased knee joint loads during walking are present in subjects with knee osteoarthri... 16558248 - Comparison of inversion restraint provided by ankle prophylactic devices before and aft... 20131658 - Pneumatic muscle actuator for resistive exercise in microgravity: test with a leg model. 20066168 - Endothelial function as a possible significant determinant of cardiac function during e... 21495078 - Interim follow-up of a randomized controlled trial comparing chinese style mind body (t... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-17 |
Journal Detail:
|
Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: - ISSN: 1532-6551 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Radiology, Emory University School of Medicine, 1364 Clifton Rd. NE, Atlanta, GA, 30322, USA, ccooke@emory.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Family Physicians' Awareness and Knowledge of the Genetic Information Non-Discrimination Act (GINA).
Next Document: The role of central CB2 cannabinoid receptors on food intake in neonatal chicks.