| Left ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high-risk individuals with long QT syndrome. | |
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MedLine Citation:
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PMID: 18940888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The aim of this study was to investigate whether prolonged and dispersed myocardial contraction duration assessed by tissue Doppler imaging (TDI) may serve as risk markers for cardiac events (documented arrhythmia, syncope, and cardiac arrest) in patients with long QT syndrome (LQTS). METHODS AND RESULTS: Seventy-three patients with genetically confirmed LQTS (nine double- and 33 single-mutation carriers with previous cardiac events and 31 single-mutation carriers without events) were studied. Myocardial contraction duration was prolonged in each group of LQTS patients compared with 20 healthy controls (P < 0.001). Contraction duration was longer in single-mutation carriers with previous cardiac events compared with those without (0.46 +/- 0.06 vs. 0.40 +/- 0.06 s, P = 0.001). Prolonged contraction duration could better identify cardiac events compared with corrected QT (QTc) interval in single-mutation carriers [area under curve by receiver-operating characteristic analysis 0.77 [95% confidence interval (95% CI) 0.65-0.89] vs. 0.66 (95% CI 0.52-0.79)]. Dispersion of contraction was more pronounced in single-mutation carriers with cardiac events compared with those without (0.048 +/- 0.018 vs. 0.031 +/- 0.019 s, P = 0.001). CONCLUSION: Dispersion of myocardial contraction assessed by TDI was increased in LQTS patients. Prolonged contraction duration was superior to QTc for risk assessment. These new methods can easily be implemented in clinical routine and may improve clinical management of LQTS patients. |
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Authors:
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Kristina Hermann Haugaa; Thor Edvardsen; Trond P Leren; Jon Michael Gran; Otto A Smiseth; Jan P Amlie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-21 |
Journal Detail:
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Title: European heart journal Volume: 30 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-02 Completed Date: 2009-03-24 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 330-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Rikshospitalet University Hospital, University of Oslo, N-0027 Oslo, Norway. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenergic beta-Antagonists / therapeutic use Adult Aged Child Echocardiography, Doppler Heart Arrest / etiology Humans Long QT Syndrome / drug therapy, genetics, physiopathology, ultrasonography* Middle Aged Mutation Myocardial Contraction / physiology Risk Assessment / methods Syncope / etiology Ventricular Function, Left Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2009 Feb;30(3):253-5
[PMID:
19151080
]
Eur Heart J. 2009 Nov;30(22):2813-4; author reply 2814-5 [PMID: 19843555 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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