Document Detail

Left ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high-risk individuals with long QT syndrome.
MedLine Citation:
PMID:  18940888     Owner:  NLM     Status:  MEDLINE    
AIMS: The aim of this study was to investigate whether prolonged and dispersed myocardial contraction duration assessed by tissue Doppler imaging (TDI) may serve as risk markers for cardiac events (documented arrhythmia, syncope, and cardiac arrest) in patients with long QT syndrome (LQTS).
METHODS AND RESULTS: Seventy-three patients with genetically confirmed LQTS (nine double- and 33 single-mutation carriers with previous cardiac events and 31 single-mutation carriers without events) were studied. Myocardial contraction duration was prolonged in each group of LQTS patients compared with 20 healthy controls (P < 0.001). Contraction duration was longer in single-mutation carriers with previous cardiac events compared with those without (0.46 +/- 0.06 vs. 0.40 +/- 0.06 s, P = 0.001). Prolonged contraction duration could better identify cardiac events compared with corrected QT (QTc) interval in single-mutation carriers [area under curve by receiver-operating characteristic analysis 0.77 [95% confidence interval (95% CI) 0.65-0.89] vs. 0.66 (95% CI 0.52-0.79)]. Dispersion of contraction was more pronounced in single-mutation carriers with cardiac events compared with those without (0.048 +/- 0.018 vs. 0.031 +/- 0.019 s, P = 0.001).
CONCLUSION: Dispersion of myocardial contraction assessed by TDI was increased in LQTS patients. Prolonged contraction duration was superior to QTc for risk assessment. These new methods can easily be implemented in clinical routine and may improve clinical management of LQTS patients.
Kristina Hermann Haugaa; Thor Edvardsen; Trond P Leren; Jon Michael Gran; Otto A Smiseth; Jan P Amlie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-21
Journal Detail:
Title:  European heart journal     Volume:  30     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-03-24     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  330-7     Citation Subset:  IM    
Department of Cardiology, Rikshospitalet University Hospital, University of Oslo, N-0027 Oslo, Norway.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Echocardiography, Doppler
Heart Arrest / etiology
Long QT Syndrome / drug therapy,  genetics,  physiopathology,  ultrasonography*
Middle Aged
Myocardial Contraction / physiology
Risk Assessment / methods
Syncope / etiology
Ventricular Function, Left
Young Adult
Reg. No./Substance:
0/Adrenergic beta-Antagonists
Comment In:
Eur Heart J. 2009 Feb;30(3):253-5   [PMID:  19151080 ]
Eur Heart J. 2009 Nov;30(22):2813-4; author reply 2814-5   [PMID:  19843555 ]

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