Document Detail

Left ventricular mass regression with amlodipine in elderly hypertensives.
MedLine Citation:
PMID:  10052647     Owner:  NLM     Status:  MEDLINE    
We evaluated effect of amlodipine therapy on left ventricular (LV) mass and function indices in 34 elderly hypertensives having echocardiographic evidence of left ventricular hypertrophy (LVH). LV mass and LV function indices were evaluated before and after 4 months of effective amlodipine therapy. Fourteen patients completed the study. Blood pressure was effectively controlled in all the patients; dose requirement of amlodipine being 5 mg/day in 8 and 10 mg/day in 6 patients. We found significant regression of LV mass indices such as thickness of interventricular septum (IVS) and left ventricular posterior wall (LVPW), and LV mass index after 4 months of amlodipine therapy. However, LV function indices did not alter following treatment. In conclusion, amlodipine therapy besides effectively controlling BP in elderly hypertensives, produced significant regression of LV mass indices without affecting the LV function.
N K Singh; S K Gupta; B V Agrawal
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  21     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:    1999 Jan-Feb
Date Detail:
Created Date:  1999-04-30     Completed Date:  1999-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
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MeSH Terms
Aged, 80 and over
Amlodipine / therapeutic use*
Blood Pressure / drug effects
Calcium Channel Blockers / therapeutic use*
Follow-Up Studies
Heart Rate / drug effects
Heart Ventricles / ultrasonography*
Hypertension / complications,  drug therapy*,  physiopathology
Hypertrophy, Left Ventricular / drug therapy*,  etiology,  physiopathology
Middle Aged
Stroke Volume / drug effects
Treatment Outcome
Reg. No./Substance:
0/Calcium Channel Blockers; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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