Document Detail


Left ventricular mass and incidence of coronary heart disease in an elderly cohort. The Framingham Heart Study.
MedLine Citation:
PMID:  2521199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the association of echocardiographically determined left ventricular mass with incidence of coronary heart disease in an elderly cohort. DESIGN: Cohort study with a follow-up period of 4 years. SETTING: Population-based. SUBJECTS: Elderly original volunteer subjects of the Framingham Heart Study who were free of clinically apparent coronary heart disease. This group included 406 men (mean age, 68 years: range, 60 to 90) and 735 women (mean age, 69 years: range, 59 to 90). MEASUREMENTS AND MAIN RESULTS: During 4 years of follow-up, coronary heart disease events occurred in 37 men and 33 women. Baseline echocardiographically determined left ventricular mass was associated with incidence of coronary disease in both sexes (P less than 0.01). After adjusting for age, systolic blood pressure, smoking, and the ratio of total/high density lipoprotein cholesterol, the relative risk for a coronary event, per 50 g/m increment in left ventricular mass/height, was 1.67 in men (95% CI, 1.24 to 2.23) and 1.60 in women (95% CI, 1.10 to 2.32). CONCLUSIONS: Echocardiographic assessment of left ventricular mass offers prognostic information beyond that provided by traditional risk factors, which can improve our ability to identify individuals at high risk for coronary heart disease. These findings may have widespread implications regarding the applications of echocardiography in clinical practice.
Authors:
D Levy; R J Garrison; D D Savage; W B Kannel; W P Castelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of internal medicine     Volume:  110     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-01-23     Completed Date:  1989-01-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-7     Citation Subset:  AIM; IM    
Affiliation:
Framingham Heart Study, Framingham, Massachusetts.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Aged, 80 and over
Cardiomegaly / complications*,  diagnosis
Cohort Studies
Coronary Disease / epidemiology*
Echocardiography*
Female
Humans
Male
Middle Aged
Prospective Studies
Risk Factors
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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