| Left ventricular mass in hereditary human hypertension: glucocorticoid-suppressible hyperaldosteronism. | |
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MedLine Citation:
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PMID: 7561013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The mineralocorticoid hormone aldosterone may be an important mediator of pathological ventricular hypertrophy and heart failure. Much of the evidence for this arises from experimental work in rat models of mineralocorticoid-dependent hypertension, and a pathological role in humans is still uncertain. SUBJECTS: Eleven subjects with glucocorticoid-suppressible hyperaldosteronism, a hereditary form of hyperaldosteronism and hypertension, and 10 age- and sex-matched control subjects were studied. RESULTS: The subjects with glucocorticoid-suppressible hyperaldosteronism had a higher mean blood pressure and plasma aldosterone concentration, and lower plasma renin concentration, than the control subjects. Left ventricular mass index was not significantly different in the subjects with glucocorticoid-suppressible hyperaldosteronism than in the control subjects. When the subjects with glucocorticoid-suppressible hyperaldosteronism were subdivided into those with and those without hypertension, no difference in left ventricular mass index could be detected between the subgroups or between either subgroup and the control subjects. However, there was a significant correlation between basal plasma aldosterone and left ventricular mass index in the subjects with glucocorticoid-suppressible hyperaldosteronism (r = 0.66, P < 0.03). CONCLUSIONS: Despite marked elevations in plasma aldosterone concentrations from birth in subjects with glucocorticoid-suppressible hyperaldosteronism, left ventricular hypertrophy did not occur. The degree of hyperaldosteronism in the subjects was mild compared with other conditions and, although an effect on left ventricular mass index could be detected, the present results indicate that other factors may be necessary for the development of left ventricular hypertrophy. |
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Authors:
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A Jamieson; D Murdoch; J A Kennedy; J M Connell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 13 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-11-02 Completed Date: 1995-11-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 551-6 Citation Subset: IM |
Affiliation:
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Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aldosterone / blood Blood Pressure Child Female Genotype Glucocorticoids / pharmacology* Humans Hyperaldosteronism / complications* Hypertension / complications* Hypertrophy, Left Ventricular / etiology* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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