Document Detail

Left ventricular mass in 169 healthy children and young adults assessed by three-dimensional echocardiography.
MedLine Citation:
PMID:  17486397     Owner:  NLM     Status:  MEDLINE    
The aims of this study were to establish normal values of left ventricular (LV) mass in children and young adults using three-dimensional echocardiography (3-DE) and to compare 3-DE LV mass estimates with those obtained by conventional echocardiographic methods. We studied 169 healthy subjects aged 2-27 years by digitized 3-D, two-dimensional (2-D), and M-mode echocardiography. 3-D echocardiography was performed by using rotational acquisition of planes at 18 degrees intervals from apical view with ECG gating and without respiratory gating. 3-DE gave smaller LV mass estimates than 2-DE and M-mode echocardiography (p < 0.001). Agreement analysis resulted in a bias of -9.3 +/- 36.5 g between 3-DE and 2-DE, and -18.5 +/- 47.9 g between 3-DE and M-mode. For the analysis, the subjects were divided into five groups according to body surface area (BSA): 0.5-0.75, 0.75-1.0, 1.0-1.25, 1.25-1.5, and greater than 1.5 m(2). LV mass/BSA by 3-DE was 45.6 (5.1), 54.3 (7.7), 55.2 (7.9), 58.8 (8.1), and 65.0 (9.9) g/m(2). LV mass/end diastolic volume (EDV) by 3-DE was 0.9 (0.1) g/ml in the BSA group of 0.5-0.75 m(2) and 1.0 (0.2) g/ml in the other BSA groups. LV mass increased linearly in relation to BSA, height, and body mass (r = 0.93, 0.90, and 0.92, respectively; p < 0.001 for all). The results showed a linear increase in LV mass, whereas LV mass/EDV ratio remained unchanged. However, LV mass estimates by 3-DE were lower than those obtained by 2-DE and M-mode echocardiography. The data obtained by 3-DE from 169 healthy subjects will serve as a reference for further studies in patients with various cardiac abnormalities.
T Poutanen; E Jokinen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-05
Journal Detail:
Title:  Pediatric cardiology     Volume:  28     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-05-16     Completed Date:  2007-08-23     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-7     Citation Subset:  IM    
Department of Pediatrics, Tampere University Hospital, P.O. Box 2000, FIN 33521, Tampere, Finland.
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MeSH Terms
Body Surface Area
Child, Preschool
Echocardiography, Three-Dimensional / methods*
Heart Ventricles / anatomy & histology,  ultrasonography*
Organ Size
Reference Values
Statistics, Nonparametric

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