| Left ventricular isovolumic relaxation and renin-angiotensin system in the growth restricted fetus. | |
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MedLine Citation:
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PMID: 18722896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine left ventricular isovolumic relaxation time (LV IRT) in normally developing and growth restricted fetuses (FGR) as an indicator of fetal cardiac afterload and neonatal systolic blood pressure. STUDY DESIGN: A prospective longitudinal study in 124 normally developing and 47 growth restricted fetuses (FGR). LV IRT, fetal heart rate (FHR) and umbilical artery pulsatility index (PI) were determined at 2-3 week intervals starting at 22-26 weeks of gestation until delivery. Renin and angiotensin I levels were measured by radioimmunoassay in umbilical venous blood after delivery. Systolic blood pressure was measured at day 1 and day 5 of postnatal life. To evaluate the association between LV IRT, gestational age and FHR, bivariate regression analyses were performed. RESULTS: Mean LV IRT (62+/-8 ms) was 29 percent longer in FGR as compared to the normal subset (47+/-6 ms) at all gestational ages (p<0.001). Mean postnatal active plasma renin level (7.78+/-S.D. 1.03 ng/ml) and postnatal angiotensin I level (4.21+/-0.70 ng/ml) in the FGR subset were significantly higher (p<0.001) than in the normal subset (4.81+/-1.04 ng/ml, renin and 2.69+/-0.44 ng/ml, angiotensin I). There was a significant difference (p<0.01) in systolic blood pressure between the two subsets on postnatal day 1 (FGR 52+/-6 mmHg vs. normal 46+/-4 mmHg) and day 5 (FGR 76+/-5 mmHg vs. normal 60+/-6 mmHg). CONCLUSION: Left ventricular isovolumic relaxation time may act as a sensitive index of increased arterial afterload in the growth retarded fetus and may herald raised systolic blood pressure in the early neonatal period. |
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Authors:
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Pavel B Tsyvian; Tatiana V Markova; Svetlana V Mikhailova; Wim C J Hop; Juriy W Wladimiroff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 140 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-25 Completed Date: 2008-11-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 33-7 Citation Subset: IM |
Affiliation:
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Mother and Child Care Institute, Yekaterinburg, Russia. p.tsyvian@iip.uran.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensins / blood* Biological Markers Case-Control Studies Female Fetal Blood / chemistry Fetal Growth Retardation / physiopathology* Heart Rate, Fetal Humans Hypertension / blood* Infant, Newborn Pregnancy Prospective Studies Renin / blood* Renin-Angiotensin System / physiology Ventricular Function, Left / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensins; 0/Biological Markers; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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