Document Detail

Left ventricular inflow propagation velocity at pulsed wave Doppler analysis: an index of relaxation.
MedLine Citation:
PMID:  15846159     Owner:  NLM     Status:  MEDLINE    
To test whether left ventricular inflow propagation velocity at the pulsed wave Doppler analysis (IPVpw) is a useful noninvasive index of relaxation, 21 patients under coronary angiography for chest pain were included for simultaneous catheter-based and Doppler studies. IPVpw was derived through the application of range ambiguity, and the time constant of isovolumic left ventricular pressure decline (tau) was acquired by a previously described method. At baseline status, IPVpw correlated significantly with the peak negative dP/dt and tau ( r = -0.609, P = .003), but not with the peak velocity of transmitral early flow (E) wave. Sublingual application of nitroglycerin increased heart rate, decreased the transmitral E velocity and transmitral E-to-A velocity ratio, and prolonged the deceleration time of the transmitral E wave. However, there was no significant impact on IPVpw, peak negative dP/dt, or tau. IPVpw correlated with tau ( r = -0.533, P < .001) at the combined analysis of the data before and after nitroglycerin application. In conclusion, IPVpw is a preload-independent, noninvasive index of left ventricular relaxation.
Wen-Chol Voon; Ho-Ming Su; Tsung-Hsien Lin; Ming-Yi Lee; Chien-Tsai Lin; Hsueh-Wei Yen; Wen-Ter Lai; Sheng-Hsiung Sheu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  18     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-22     Completed Date:  2005-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  326-9     Citation Subset:  IM    
Department of Internal Medicine, Kaohsiung Medical University, Taiwan.
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MeSH Terms
Blood Flow Velocity / physiology
Echocardiography, Doppler, Pulsed*
Heart Catheterization
Heart Rate / drug effects
Middle Aged
Nitroglycerin / administration & dosage
Ventricular Dysfunction, Left / physiopathology*,  ultrasonography*
Reg. No./Substance:

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