Document Detail


Left ventricular hypertrophy induced by abdominal aortic banding and its prevention by angiotensin receptor blocker telmisartan--a proteomic analysis.
MedLine Citation:
PMID:  20697985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac hypertrophy is frequently caused by pressure overload (i.e., high blood pressure or hypertension) and can lead to heart failure. The major objective of the present study was to investigate the proteomic changes in response to the development of left ventricular hypertrophy (LVH) induced by abdominal aortic banding (AB) and its prevention by antihypertensive treatment with angiotensin II receptor blocker (ARB) telmisartan. One week after AB and Sham surgery, rats were assigned into three groups: SHAM-control, aortic banding without treatment (AB-Ctrl) and aortic banding with telmisartan treatment (AB-Telmi; 5mg/kg/day for 8 weeks). Echocardiography, hemodynamics, and pathology were performed to assess LVH. Left ventricular myocardium was sampled. The analysis of proteomic proteins from myocardium was performed by two-dimensional gel electrophoresis and MALDI-TOF-MS. In AB-Ctrl, heart rate, systolic arterial blood pressure, diastolic blood pressure, left ventricular end systolic pressure, interventricular septal thickness at diastole, posterior wall thickness in diastole, heart weight (HW) and HW/body weight (BW) were increased, indicating that both hypertension and LVH developed. Telmisartan prevented hypertension and LVH. Concurrently, among numerous proteins, there were 17 that were differentially expressed among hypertrophic hearts, normal hearts, and the hearts where hypertrophic response was suppressed by ARB treatment. Primarily, proteins involved in cell structure, metabolism, stress and signal transduction exhibited up-regulations in LVH, providing cellular and molecular mechanism for hypertrophic development. These changes were prevented or greatly attenuated by telmisartan regimen. Interestingly, antioxidative-related heat shock protein 2 was detected neither in SHAM-Ctrl nor in AB-Ctrl, but in AB-Telmi. LVH is accompanied by series changes of protein expression. Both LVH and proteomic changes can be prevented by blockade of renin-angiotensin system with telmisartan. These protein alterations may constitute mechanistic pathways leading to hypertrophy development and experimental targets for novel therapeutic strategy.
Authors:
Li Liu; Wen Wang; Xianmin Meng; Jiuming Gao; Haiying Wu; Peihe Wang; Weichun Wu; Linlin Wang; Liyuan Ma; Weiguo Zhang
Related Documents :
1825095 - Echocardiographic evaluation of cardiac structure and function in elderly subjects with...
140025 - Isolation and characterization of myosin from subjects with asymmetric septal hypertrophy.
156735 - Effects of exerimental right ventricular hypertrophy on myocardial blood flow in consci...
8638865 - Ace inhibition with spirapril improves diastolic function at rest independent of vasodi...
2030815 - Singing-induced hypotension: a complication of a high spinal cord lesion.
2337155 - 1/f fluctuations in arterial pressure and regulation of renal blood flow in dogs.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-10
Journal Detail:
Title:  Journal of physiology and biochemistry     Volume:  66     ISSN:  1138-7548     ISO Abbreviation:  J. Physiol. Biochem.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-02     Completed Date:  2011-01-13     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9812509     Medline TA:  J Physiol Biochem     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  329-38     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angiotensin Receptor Antagonists / pharmacology*
Animals
Aorta / pathology
Aorta, Abdominal / drug effects,  pathology*
Benzimidazoles / pharmacology*
Benzoates / pharmacology*
Blood Pressure
Echocardiography / methods
Electrophoresis, Gel, Two-Dimensional
Heart Failure / etiology
Hypertrophy, Left Ventricular / drug therapy,  pathology*
Male
Proteomics / methods*
Rats
Rats, Sprague-Dawley
Renin-Angiotensin System
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Chemical
Reg. No./Substance:
0/Angiotensin Receptor Antagonists; 0/Benzimidazoles; 0/Benzoates; U5SYW473RQ/telmisartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Formulation and in vitro characterization of Eudragit® L100 and Eudragit® L100-PLGA nanoparticles ...
Next Document:  Clinical presentation of carcinoma of unknown primary: 14 years of experience.