Document Detail

Left ventricular hypertrophy in spontaneously hypertensive rat: effects of ACE-inhibition on myocardiocyte ultrastructure.
MedLine Citation:
PMID:  8685076     Owner:  NLM     Status:  MEDLINE    
The aim of this study is to investigate the effects of two ACE-inhibitors with different chemical formulae, cilazapril (CLZ) and captopril (CPT), on left ventricular myocardiocytes from spontaneously hypertensive rats (SHR), characterized by ultrastructural alterations associated with left ventricular hypertrophy, and from Wistar-Kyoto (WKY) rats, considered as controls. After CLZ-treatment, not remarkable changes are observed in WKY myocardiocytes, whereas SHR ones show a considerable reduction in their original alterations in ultrastructure. After CPT-treatment, both SHR and WKY myocardiocytes are altered in ultrastructure. The morphometric investigation confirms that CPT and CLZ produce different effects. Even if the drugs induce a similar decrease in blood pressure and left ventricular mass index, CLZ unlike CPT seems to improve the ultrastructural abnormalities associated with left ventricular hypertrophy. These changes could be related to the different chemical structure of CLZ and CPT, or to a different affinity of the two drugs for the local renin-angiotensin system.
V Vulpis; T M Seccia; B Nico; S Ricci; L Roncali; A Pirrelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  31     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1996-08-20     Completed Date:  1996-08-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  375-81     Citation Subset:  IM    
DIMO, Department of Biomedical Sciences and Human Oncology, University of Bari, Italy.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Blood Pressure / drug effects
Captopril / pharmacology
Cardiomegaly / etiology,  pathology*
Cilazapril / pharmacology
Heart Rate / drug effects
Hypertension / chemically induced,  complications*
Myocardium / ultrastructure*
Rats, Inbred SHR
Rats, Inbred WKY
Time Factors
Ventricular Function, Left / drug effects*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 62571-86-2/Captopril; 92077-78-6/Cilazapril

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