| Left ventricular hypertrophy in hypertensive type 2 diabetic patients according to renal function. | |
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MedLine Citation:
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PMID: 19423378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Cardiovascular disease is the main cause of death in diabetic patients undergoing haemodialysis. Dialysis and hypertension increase left ventricular hypertrophy (LVH), a strong predictor of cardiovascular events. This study evaluated left ventricular structure and function in three groups of hypertensive type 2 diabetic patients with different renal function, and assessed the factors associated with LVH, in an Afro-Caribbean population. METHODS: Left ventricular structure and function were measured by ultrasonography. Group 1 consisted of 150 patients with normal renal function, group 2 included 183 patients with renal dysfunction and the third group comprised 75 dialysis patients. RESULTS: Left ventricular mass/height(2.7) increased from group 1 to groups 2 and 3 (49.00g/m(2.7), 57.12g/m(2.7) and 59.75g/m(2.7), respectively; P<0.0001). The prevalences of LVH were 48.3% in group 1, 64.8% in group 2 and 70.3% in the dialysis patients (P=0.001). LVH was more concentric than eccentric in groups 2 and 3. The factors significantly associated with LVH were obesity in groups 1 and 2, and an increase of 10mmHg in pulse pressure in groups 2 and 3, according to multivariate logistic-regression analysis. CONCLUSION: Our study confirmed that, in a population of Afro-Caribbean hypertensive type 2 diabetic patients, renal failure was associated to an increased left ventricular mass/height(2.7). The data show that the variables associated with LVH differ according to renal profile. This finding will be of value in the treatment and follow-up of these patients. |
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Authors:
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A Blanchet Deverly; P Kangambega; K Hue; J-P Donnet; H Merault; L Foucan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-06 |
Journal Detail:
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Title: Diabetes & metabolism Volume: 35 ISSN: 1878-1780 ISO Abbreviation: Diabetes Metab. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-28 Completed Date: 2010-01-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607599 Medline TA: Diabetes Metab Country: France |
Other Details:
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Languages: eng Pagination: 280-6 Citation Subset: IM |
Affiliation:
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CHU de Point-??-Pitre Abymes, Guadeloupe. anne.blanchet.deverly@wanadoo.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antihypertensive Agents / therapeutic use Cardiovascular Diseases / etiology Cross-Sectional Studies Diabetes Mellitus, Type 2 / complications*, ethnology, physiopathology Echocardiography Female Humans Hypertension / complications*, ethnology, physiopathology Hypertrophy, Left Ventricular / classification, etiology*, physiopathology Kidney Failure / complications* Kidney Function Tests Male Middle Aged Obesity / complications Renal Dialysis / statistics & numerical data Risk Factors Statistics as Topic |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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