| Left ventricular hypertrophy in asymptomatic essential hypertension: its relationship with aldosterone and the increase in sodium-proton exchanger activity. | |
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MedLine Citation:
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PMID: 8281961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to analyse the hormonal and erythrocyte ion transport systems in relation to left ventricular hypertrophy (LV) in essential hypertension, a prospective study of 50 consecutive hypertensive patients under 55 years of age and without prior antihypertensive therapy was performed. Twenty-seven normal subjects with no family history of hypertension served as controls. LV hypertrophy, as assessed by echocardiography, was present in 64% of the hypertensive patients. This showed an increase (P < 0.001) in intra-erythrocyte Na+ concentration (8.1 +/- 1.2 vs 6.9 +/- 1 mmol.l-1.cells-1) and Na+:H+ exchange activity (8.8 +/- 4 vs 5.5 +/- 1.3 mmol.[l.cells.h-1]). There was a significant association between plasma aldosterone levels (19.1 +/- 12 ng.dl-1) with intra-erythrocyte Na+ content (r = 0.370, P < 0.05) and Na+:H+ exchange activity (r = 0.385, P < 0.01) as well as with echocardiographic LV mass index (138 +/- 40 g.m-2, r = 0.393, P < 0.01). The results are consistent with the concept that increased entry of Na+ into cells via Na+:H+ exchange could be a determining factor in left ventricular hypertrophy, which might be influenced by aldosterone. |
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Authors:
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F Navarro-Lopez; A Coca; J C Pare; A De La Sierra; X Bosch; A Urbano Marquez |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European heart journal Volume: 14 Suppl J ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-02-14 Completed Date: 1994-02-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 38-41 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Hospital Clínico-University of Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aldosterone / blood* Blood Pressure Case-Control Studies Erythrocytes / metabolism Female Humans Hydrogen / metabolism* Hypertension / complications, metabolism*, physiopathology Hypertrophy, Left Ventricular / etiology, metabolism*, ultrasonography Ion Transport Male Middle Aged Prospective Studies Sodium / metabolism* |
| Chemical | |
Reg. No./Substance:
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1333-74-0/Hydrogen; 52-39-1/Aldosterone; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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