Document Detail

Left ventricular hypertrophy in asymptomatic essential hypertension: its relationship with aldosterone and the increase in sodium-proton exchanger activity.
MedLine Citation:
PMID:  8281961     Owner:  NLM     Status:  MEDLINE    
In order to analyse the hormonal and erythrocyte ion transport systems in relation to left ventricular hypertrophy (LV) in essential hypertension, a prospective study of 50 consecutive hypertensive patients under 55 years of age and without prior antihypertensive therapy was performed. Twenty-seven normal subjects with no family history of hypertension served as controls. LV hypertrophy, as assessed by echocardiography, was present in 64% of the hypertensive patients. This showed an increase (P < 0.001) in intra-erythrocyte Na+ concentration (8.1 +/- 1.2 vs 6.9 +/- 1 mmol.l-1.cells-1) and Na+:H+ exchange activity (8.8 +/- 4 vs 5.5 +/- 1.3 mmol.[l.cells.h-1]). There was a significant association between plasma aldosterone levels (19.1 +/- 12 ng.dl-1) with intra-erythrocyte Na+ content (r = 0.370, P < 0.05) and Na+:H+ exchange activity (r = 0.385, P < 0.01) as well as with echocardiographic LV mass index (138 +/- 40 g.m-2, r = 0.393, P < 0.01). The results are consistent with the concept that increased entry of Na+ into cells via Na+:H+ exchange could be a determining factor in left ventricular hypertrophy, which might be influenced by aldosterone.
F Navarro-Lopez; A Coca; J C Pare; A De La Sierra; X Bosch; A Urbano Marquez
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  14 Suppl J     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-14     Completed Date:  1994-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  38-41     Citation Subset:  IM    
Department of Cardiology, Hospital Clínico-University of Barcelona, Spain.
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MeSH Terms
Age Factors
Aldosterone / blood*
Blood Pressure
Case-Control Studies
Erythrocytes / metabolism
Hydrogen / metabolism*
Hypertension / complications,  metabolism*,  physiopathology
Hypertrophy, Left Ventricular / etiology,  metabolism*,  ultrasonography
Ion Transport
Middle Aged
Prospective Studies
Sodium / metabolism*
Reg. No./Substance:
1333-74-0/Hydrogen; 52-39-1/Aldosterone; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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