Document Detail


Left ventricular hypertrophy by electrocardiography and echocardiography in the African American Study of Kidney Disease Cohort Study.
MedLine Citation:
PMID:  22341790     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although electrocardiographic criteria for diagnosing left ventricular hypertrophy have a low sensitivity in the general population, their test characteristics have not been evaluated in the high-prevalence group of American Americans with chronic kidney disease. The purpose of the current study was to evaluate these test characteristics among African Americans (n = 645) with hypertensive kidney disease as part of the African-American Study of Kidney Disease and Hypertension cohort. Electrocardiograms were read by 2 cardiologists at an independent core laboratory using the 2 Sokolow-Lyon criteria and the Cornell criteria. Left ventricular hypertrophy on echocardiography was defined as left ventricular mass index greater than 49.2 and greater than 46.7 g/m(2.7) in men and women, respectively. Sixty-nine percent of the population had left ventricular hypertrophy on echo, whereas 34% had left ventricular hypertrophy by any of the electrocardiographic criteria. Sensitivity by individual electrocardiographic criteria was 16.5% by Sokolow-Lyon-1, 19.3% by Sokolow-Lyon-2, and 24.7% by Cornell criteria, with specificity ranging from 89% to 92%. When using any of the 3 criteria, sensitivity increased to 40.4% with a decrease in specificity to 78.0%. Consistent with findings in a general population, left ventricular hypertrophy by electrocardiography had low sensitivity and high specificity in this cohort of African Americans with hypertensive kidney disease.
Authors:
Ricardo Esquitin; Louai Razzouk; Gail E Peterson; Jackson T Wright; Robert A Phillips; Tine L De Backer; David A Baran; Cynthia Kendrick; Tom Greene; James Reiffel; Paul Muntner; Michael E Farkouh
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-02-16
Journal Detail:
Title:  Journal of the American Society of Hypertension : JASH     Volume:  6     ISSN:  1878-7436     ISO Abbreviation:  J Am Soc Hypertens     Publication Date:    2012 May-Jun
Date Detail:
Created Date:  2012-04-23     Completed Date:  2012-09-20     Revised Date:  2013-02-06    
Medline Journal Info:
Nlm Unique ID:  101312518     Medline TA:  J Am Soc Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-200     Citation Subset:  IM    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Beth Israel Deaconess Medical Center, Boston, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use
African Americans*
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Calcium Channel Blockers / therapeutic use
Disease Progression
Drug Therapy, Combination
Echocardiography / methods*
Electrocardiography / methods*
Female
Follow-Up Studies
Humans
Hypertension, Renal / complications*,  drug therapy,  ethnology
Hypertrophy, Left Ventricular / diagnosis*,  ethnology,  etiology
Incidence
Kidney Failure, Chronic / complications,  diagnosis,  ethnology*
Male
Middle Aged
Prevalence
Prospective Studies
ROC Curve
Reproducibility of Results
United States / epidemiology
Grant Support
ID/Acronym/Agency:
2P20 RR11104/RR/NCRR NIH HHS; 5M01 RR-00071/RR/NCRR NIH HHS; DK 2818-02/DK/NIDDK NIH HHS; M01 00032//PHS HHS; M01 RR00052/RR/NCRR NIH HHS; M01 RR00827/RR/NCRR NIH HHS; P20-RR11145/RR/NCRR NIH HHS; UL1 RR024989/RR/NCRR NIH HHS; UL1 RR024989/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers

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