Document Detail

Left ventricular hypertrophy is associated with an attenuated endothelium-dependent vasodilation in hypertensive men.
MedLine Citation:
PMID:  11212058     Owner:  NLM     Status:  MEDLINE    
To investigate the relationship between left ventricular hypertrophy (LVH) and endothelium-dependent vasodilation (EDV), 30 untreated hypertensive patients, 18 treated hypertensives (53 +/- 7 years, all males) and 26 age-and sex-matched healthy normotensive controls, underwent evaluation of EDV and endothelium-independent vasodilation (EIDV) in the forearm, by means of local intra-arterial infusions of methacholine (MCh, evaluating EDV) and sodium nitroprusside (SNP, evaluating EIDV). Forearm blood flow was measured by venous occlusion plethysmography and LVH was measured by echocardiography. The reduction in forearm vascular resistance during MCh infusion (4 microg/min) was significantly smaller in the hypertensive patients with LVH when compared to those without LVH, both in the untreated (-61 +/- 12%, n = 19 vs -72 +/- 4%, n = 11, p < 0.01) and in the treated group (-60 +/- 15%, n = 11 vs -75 +/- 5%, n = 7, p < 0.01). Thereby, EDV was significantly impaired only in the hypertensive patients with LVH when compared to controls (-77 +/- 7% at MCh 4 microg/min, p < 0.001). EIDV was not significantly different between patients with and without LVH and controls. In conclusion, the presence of LVH was related to endothelial dysfunction, both in untreated and treated hypertensive patients, suggesting either a role for endothelial function in the development of LVH, or that a dysfunctional endothelium and LVH are coexisting markers of a more severe hypertensive disease.
J Millgård; A Hägg; T Kahan; J Landelius; K Malmqvist; M Sarabi; L Lind
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure     Volume:  9     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  2000  
Date Detail:
Created Date:  2001-02-09     Completed Date:  2001-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
Department of Internal Medicine, University Hospital of Uppsala, Sweden.
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MeSH Terms
Age Factors
Analysis of Variance
Endothelium, Vascular / physiopathology
Forearm / blood supply
Hypertension / complications,  physiopathology*
Hypertrophy, Left Ventricular / complications,  physiopathology*
Matched-Pair Analysis
Methacholine Chloride / administration & dosage,  pharmacology
Middle Aged
Nitroprusside / administration & dosage,  pharmacology
Regional Blood Flow / drug effects,  physiology
Vasodilation / drug effects,  physiology*
Reg. No./Substance:
15078-28-1/Nitroprusside; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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