Document Detail

Left ventricular hypertrophy as a risk factor in arterial hypertension.
MedLine Citation:
PMID:  1396865     Owner:  NLM     Status:  MEDLINE    
Data on the evolution and prognostic implications of left ventricular hypertrophy (LVH) determined by ECG, chest X-ray and echocardiogram in the Framingham Study are reviewed. Echocardiographic examination provides the most sensitive and specific measure of left ventricular hypertrophy, providing a quantitative evaluation of the anatomical condition. Chest X-ray evaluation is also more sensitive than the ECG, but less specific than the echocardiogram. When ECG-LVH is present, X-ray and echocardiographic LVH are often found; but, when negative, the ECG clearly does not exclude anatomical LVH. The incidence of each variety of LVH increases with age, weight and blood pressure. Although it may also appear following coronary heart disease (CHD), valvular deformity and congenital cardiac defects, the former are the major determinants of LVH in the general population. Each contributes independently to the occurrence of LVH. LVH has emerged as a powerful non-invasive indicator of increased vulnerability to the occurrence of major cardiovascular disease outcomes in hypertension. It appears that X-ray and echocardiographic LVH measure anatomical hypertrophy, whereas the ECG variety is also indicative of ischaemic myocardial involvement when repolarization abnormality is present. Hypertension clearly predisposes to both anatomical and ECG-LVH which cannot be taken as an incidental compensatory feature since at any blood pressure those with ECG-LVH, X-ray or echo LVH are distinctly more prone to cardiovascular sequelae. ECG-LVH carries a greater risk than anatomical (X-ray) LVH. ECG-LVH with repolarization abnormality is more dangerous than that with voltage alone. The latter appears to reflect chiefly the severity and duration of accompanying hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)
W B Kannel
Related Documents :
16957565 - Low triiodothyronine and cardiomyopathy in patients with end-stage renal disease.
20087295 - Relations between haemoglobin mass, cardiac dimensions and aerobic capacity in enduranc...
20107905 - Body size adjustments for left ventricular mass by cardiovascular magnetic resonance an...
17266575 - Left ventricular hypertrophy: a shift in paradigm.
24385995 - Repeated aborted sudden cardiac death with long qt syndrome in a patient with anomalous...
10453605 - A comparative observation on treatment of heart failure due to diastolic insufficiency ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European heart journal     Volume:  13 Suppl D     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-23     Completed Date:  1992-11-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  82-8     Citation Subset:  IM    
Department of Medicine, Evans Memorial Research Foundation, Boston University School of Medicine.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Coronary Disease / physiopathology,  ultrasonography
Hypertension / physiopathology*,  ultrasonography
Hypertrophy, Left Ventricular / physiopathology*,  ultrasonography
Middle Aged
Risk Factors
Ventricular Function, Left / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Electrophysiological and therapeutic implications of cardiac arrhythmias in hypertension.
Next Document:  The role of hypertension, left ventricular hypertrophy and psychosocial risks in cardiovascular dise...