| Left ventricular hemodynamics during respiration. | |
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MedLine Citation:
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PMID: 536301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have investigated the mechanisms involved in the inspiratory fall in left ventricular stroke volume (LVSV), utilizing a spontaneously breathing dog on right-heart bypass (RHBP). We have been able to control lung volume, pulmonary artery inflow, and right-heart volume (RHV). During Mueller maneuvers in one series, RHV was allowed to increase as pleural pressure (Ppl) fell; in a second series, changes in RHV were excluded. In both series LVSV fell significantly, associated with a significant rise in the transmural (relative to Ppl) aortic diastolic pressure, reflecting an increase in the effective LV afterload. The transmural left ventricular filling pressure did not fall, a fact inconsistent with decreased pulmonary venous return, causing the fall in LVSV. The LVSV fell significantly more when RHV was allowed to increase as when it was held constant with all other variables showing no statistical change. Thus, increases in both RHV and effective LV afterload are created by the inspiratory fall in Ppl and summate to decrease LVSV. |
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Authors:
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J L Robotham; J Rabson; S Permutt; B Bromberger-Barnea |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology: respiratory, environmental and exercise physiology Volume: 47 ISSN: 0161-7567 ISO Abbreviation: J Appl Physiol Publication Date: 1979 Dec |
Date Detail:
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Created Date: 1980-05-23 Completed Date: 1980-05-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7801242 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1295-1303 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Obstruction
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physiopathology Animals Blood Pressure Cardiac Output* Cardiac Tamponade / physiopathology Cardiac Volume Cardiopulmonary Bypass Dogs Heart / physiology* Heart Ventricles Lung / physiology Pleura / physiology Pressure Pulse Respiration* Stroke Volume* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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