| Left ventricular geometry in patients with obstructive sleep apnea coexisting with treated systemic hypertension. | |
| | |
MedLine Citation:
|
PMID: 16439828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Left ventricular (LV) hypertrophy is a common consequence of systemic hypertension (SH) and obstructive sleep apnea (OSA). However, little is known about the degree of LV involvement in patients with OSA coexisting with treated SH. OBJECTIVES: Our study was designed in order to assess the prevalence of distinct types of LV geometry in treated hypertensive OSA patients. METHODS: PATIENTS: 183 patients with treated SH were enrolled to the study. Group 1 consisted of 38 patients with newly-diagnosed OSA and ineffectively treated SH. The remaining 145 patients with effectively treated SH were divided into three groups: group 2 - 70 patients with newly-diagnosed OSA, group 3 - 31 patients with OSA treated with continuous positive airway pressure (CPAP), and group 4 - 44 patients without OSA. Overnight sleep studies and M-mode echocardiography were performed. RESULTS: LV mass index did not differ between the study groups. Mean values of LV end-diastolic diameter (LVED) were 55.4 +/- 6.8 mm in group 1 and 53.6 +/- 6.9 mm in group 2 and were significantly increased in comparison to subjects treated with CPAP and controls (49.8 +/- 6.8 mm and 50.1 +/- 64.7 mm, respectively; p = 0.001). LVED correlated positively with the apnea-hypopnea index and desaturation index. LV eccentric hypertrophy was the commonest type of LV geometry in newly-diagnosed OSA patients. CONCLUSIONS: The major finding of our study is the predominance of LV eccentric hypertrophy in newly-diagnosed OSA patients. We suggest that a relatively moderate degree of LV involvement in hypertensive OSA patients may depend on the cardioprotective effect of concomitant antihypertensive therapy, ameliorating OSA-dependent neurohumoral abnormalities. |
| | |
Authors:
|
Wojciech Myslinski; Hans-Werner Duchna; Kurt Rasche; Manuel Dichmann; Jerzy Mosiewicz; Gerhard Schultze-Werninghaus |
Related Documents
:
|
12415228 - Doppler tissue echocardiographic features of cardiac amyloidosis. 10559078 - Echocardiographic predictors of an adverse response to a nifedipine trial in primary pu... 19959248 - Percutaneous closure of perimembranous ventricular septal defect with an amplatzer duct... 12848658 - Echocardiographic features of patients with heart failure who may benefit from biventri... 22563198 - Differences between diffuse and focal autoimmune pancreatitis. 19813068 - The heart in sporadic inclusion body myositis: a study in 51 patients. |
Publication Detail:
|
Type: Journal Article Date: 2006-01-26 |
Journal Detail:
|
Title: Respiration; international review of thoracic diseases Volume: 74 ISSN: 0025-7931 ISO Abbreviation: Respiration Publication Date: 2007 |
Date Detail:
|
Created Date: 2007-02-23 Completed Date: 2007-04-17 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0137356 Medline TA: Respiration Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 176-83 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, University School of Medicine, Lublin, Poland. misl@poczta.wprost.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antihypertensive Agents
/
therapeutic use* Blood Pressure / physiology Echocardiography Heart Ventricles / physiopathology, ultrasonography* Humans Hypertension / complications*, drug therapy, physiopathology Male Middle Aged Polysomnography Severity of Illness Index Sleep Apnea, Obstructive / complications*, physiopathology, ultrasonography Stroke Volume / physiology Ventricular Function, Left / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Factors related to institutionalization among the frail elderly with home-visiting nursing service i...
Next Document: Cochlear electrode arrays: past, present and future.