| Left ventricular geometry and arterial function in hypercholesterolemia. | |
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MedLine Citation:
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PMID: 11887428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To investigate the effect of hypercholesterolemia on total arterial compliance and left ventricular (LV) geometry in the absence of arterial hypertension and diabetes. METHODS: One hundred and fifty-two normotensive, non-diabetic patients (109 men) aged 52 +/- 10 years with plasma cholesterol > 240 mg/100 mL, and 282 normotensive controls (154 men) aged 42 +/- 10 years (p < 0.0001) with plasma cholesterol < 200 mg/100 mL were studied by means of echocardiography. The stroke volume/pulse pressure ratio as a percentage of the value predicted by individual age, body weight and heart rate was used as a prognostically-validated index of total arterial compliance. Central pulse pressure (PP) was estimated using a regression equation obtained in a non-overlapping population. RESULTS: Although within the "normal" range, systolic pressure, PP and estimated central PP were higher in the hypercholesterolemic patients even after controlling for differences in age, body mass index (BMI) and race (all p < 0.0001). After controlling for differences in systolic pressure, age, BMI and race, LV mass and the prevalence of hypertrophy were comparable between the two groups, whereas relative diastolic wall thickness was greater (0.36 + 0.06 vs 0.33 + 0.05) and percent SV/PP (stroke volume/PP) lower in the hypercholesterolemic patients (96 +/- 19% vs 102 +/- 18%; both p < 0.005). After considering the covariates, there was still an independent negative correlation between relative wall thickness and percent SV/PP (r = -0.37, p < 0.0001). CONCLUSIONS: Hypercholesterolemia in normotensive non-diabetic adults is independently associated with a mildly concentric LV geometry and a reduced index of total arterial compliance. |
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Authors:
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A Celentano; M Crivaro; M J Roman; I Pietropaolo; R Greco; P Pauciullo; C Lirato; R B Devereux; G de Simone |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nutrition, metabolism, and cardiovascular diseases : NMCD Volume: 11 ISSN: 0939-4753 ISO Abbreviation: Nutr Metab Cardiovasc Dis Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2002-03-12 Completed Date: 2002-10-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9111474 Medline TA: Nutr Metab Cardiovasc Dis Country: Italy |
Other Details:
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Languages: eng Pagination: 312-9 Citation Subset: IM |
Affiliation:
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Department of Clinical and Experimental Medicine, Federico II University Hospital, School of Medicine, Naples, Italy. alcelent@unina.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Body Mass Index Cholesterol / blood* Compliance Echocardiography Female Heart Ventricles / anatomy & histology, pathology Hemodynamics Humans Hypercholesterolemia / pathology, physiopathology* Hypertrophy, Left Ventricular / pathology, physiopathology* Male Middle Aged Stroke Volume Tunica Intima / anatomy & histology, physiology Ventricular Function Ventricular Function, Left / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-18323/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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