| Left ventricular functional improvement after transmyocardial laser revascularization. | |
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MedLine Citation:
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PMID: 9768921 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Transmyocardial laser revascularization has been used to treat patients with end-stage coronary artery disease that is not amenable to standard revascularization. Although there is evidence of angina relief and quality of life enhancement, there is little information concerning improvement in myocardial contractility. The purpose of this study was to determine whether transmyocardial laser revascularization improves myocardial function in chronically ischemic myocardium. METHODS: In a model of chronic ischemia by Ameroid occlusion of the circumflex artery, domestic pigs (n = 8) were treated with transmyocardial laser revascularization. Before laser treatment, segmental contraction was assessed at rest and with dobutamine stress echocardiography. Myocardium subtended by the occlusion was compared with that remote from the occlusion. Six weeks after transmyocardial laser revascularization, the animals were restudied at rest and with stress, and then sacrificed. Sham-treated control animals (n = 4) underwent the same procedures but were not treated with transmyocardial laser revascularization. Control animals did not demonstrate significant recovery of function. RESULTS: Transmyocardial laser revascularization improved resting function in chronically ischemic myocardium by 100%. CONCLUSIONS: Transmyocardial laser revascularization significantly improves the function of chronically ischemic myocardium. These data may help explain the mechanisms by which transmyocardial laser revascularization is clinically effective. |
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Authors:
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K A Horvath; R Greene; N Belkind; B Kane; D D McPherson; D A Fullerton |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 66 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-10-21 Completed Date: 1998-10-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 721-5 Citation Subset: AIM; IM |
Affiliation:
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Feinberg Cardiovascular Research Institute, Northwestern University Medical School, Chicago, Illinois 60611, USA. khorvath@nmh.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Disease / surgery* Female Image Processing, Computer-Assisted Laser Therapy* Male Myocardial Contraction Myocardial Ischemia / surgery Myocardial Revascularization / methods* Swine Treatment Outcome Ventricular Function, Left* |
| Comments/Corrections | |
Comment In:
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Ann Thorac Surg. 1999 Nov;68(5):1893-4
[PMID:
10585099
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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