Document Detail

Left ventricular function in mild hypertension after adrenergic blockade.
MedLine Citation:
PMID:  3346069     Owner:  NLM     Status:  MEDLINE    
We previously used the Doppler transmitral flow velocity ratio A/E (A = late ventricular filling peak velocity; E = early ventricular filling peak velocity) and the age-adjusted ratio A/E/Age to detect left ventricular filling abnormalities in untreated mild hypertension. This study is a double-blind assessment of the effect of combined alpha- and beta-blockade (labetalol) and beta-blockade alone (atenolol) on left ventricular filling in mild hypertension. Twenty-seven patients blindly randomized to labetalol (12 patients) and atenolol (15 patients) treatment completed the echocardiographic and Doppler studies. Clinical and echo-Doppler data obtained at baseline and 6 weeks after initiation of therapy showed no difference between the two groups for age (49 +/- 10 vs 46 +/- 10 years), mean blood pressure (before therapy, 118 +/- 9 vs 117 +/- 8 mm Hg; after therapy, 108 +/- 12 mm Hg), left ventricular dimensions, wall thickness, systolic function, and mean late filling velocity A. There was no significant change in left ventricular mass and mass index with labetalol (left ventricular mass, 211 +/- 36 vs 216 +/- 38; mass index, 110 +/- 17 vs 112 +/- 16) or atenolol (245 +/- 41 vs 271 +/- 65; 120 +/- 18 vs 130 +/- 35). The mean velocity E, A/E, and A/E/Age ratios significantly improved with labetalol (p less than 0.05) but did not change significantly with atenolol. The improvement in A/E and A/E/Age ratios was primarily due to an increase in early filling velocity E.(ABSTRACT TRUNCATED AT 250 WORDS)
S B Dianzumba; D DiPette; C R Joyner; R Townsend; E Weber; K Mauro; C Cornman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  11     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-04-11     Completed Date:  1988-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I98-102     Citation Subset:  IM    
Department of Medicine, Allegheny General Hospital, Allegheny-Singer Research Institute, Pittsburgh, PA 15212.
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MeSH Terms
Atenolol / therapeutic use*
Double-Blind Method
Hypertension / drug therapy*,  physiopathology
Labetalol / therapeutic use*
Middle Aged
Myocardial Contraction / drug effects*
Random Allocation
Reg. No./Substance:
29122-68-7/Atenolol; 36894-69-6/Labetalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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