Document Detail

Left ventricular function in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  6450029     Owner:  NLM     Status:  MEDLINE    
Left ventricular function was studied at rest and during post-extrasystolic potentiation (PESP) in 18 patients with chronic obstructive lung disease. The contractility indices were obtained from pressures recorded in the osovolumetric period and from volume variations during ejection. All patients were hypoxic; six of them had cor pulmonale (group B); the remaining 12 patients constituted group A. Left ventricular function was similar in both groups; it is concluded that right heart failure in cor pulmonale is not secondary to left ventricular failure. Left ventricle was hypertrophied and pump function altered, but left ventricular kinetics was normal or increased. Isovolumetric phase contractility indices were decreased; they may increase during PESP. Left ventricular compliance was altered due to left and right ventricular hypertrophy and to paradoxical movement of interventricular septum which impeded diastolic expansion of left ventricle. The impairment of left ventricular function seems to be related to both intrinsic (hypoxia, hypercapnia, hypertrophy) and extrinsic factors (right ventricular hypertrophy with deviation of interventricular septum, lowering of left ventricular preload).
C Gabinski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cor et vasa     Volume:  22     ISSN:  0010-8650     ISO Abbreviation:  Cor Vasa     Publication Date:  1980  
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372614     Medline TA:  Cor Vasa     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  238-44     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Cardiac Output
Cardiac Volume
Cardiomegaly / etiology
Heart Ventricles / physiopathology
Lung Diseases, Obstructive / complications,  physiopathology*
Middle Aged
Myocardial Contraction
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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