Document Detail

Left ventricular function, haemodynamics and certain indicators of neurohumoral control during submaximal exercise in patients with essential hypertension.
MedLine Citation:
PMID:  6347518     Owner:  NLM     Status:  MEDLINE    
The study was carried out in 22 men with essential hypertension, stage I B-II B, aged 25 to 46 years, and in 10 healthy volunteers of the same age. The authors investigated indicators of systemic and intracardiac haemodynamics by echocardiography, determined the blood plasma catecholamine concentration, catecholamine excretion, renin and cyclic nucleotides activity in plasma, both at rest and during continuous submaximal graded exercise on a bicycle ergometer. The haemodynamic response to exercise differed in patients with stable HPT from healthy subjects and patients with labile HPT by an increase in diastolic blood pressure, a lesser drop in end-systolic volume and in total peripheral vascular resistance, a lesser rise in cardiac output, and by a substantially higher left ventricular mass. The left ventricular ejection fraction did not rise in patients with stable hypertension. In these patients, no statistically significant concentration of urine catecholamines and their urine excretion was observed, in contrast to the other two groups where these indicators were increased. A negative correlation was found between the left ventricular mass and the ejection fraction during exercise, which attests to a negative influence of left ventricular hypertrophy on the pump function of the heart during exercise in patients with essential hypertension.
I K Shkhvatsabaya; A P Yurenev; E V Parfenova; E V Erina; Z M Kiseleva; S E Ustinova; N V Speranskaya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cor et vasa     Volume:  25     ISSN:  0010-8650     ISO Abbreviation:  Cor Vasa     Publication Date:  1983  
Date Detail:
Created Date:  1983-09-09     Completed Date:  1983-09-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372614     Medline TA:  Cor Vasa     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  81-91     Citation Subset:  IM    
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MeSH Terms
Catecholamines / metabolism*
Hypertension / enzymology,  metabolism,  physiopathology*
Middle Aged
Nucleotides, Cyclic / metabolism*
Physical Exertion*
Renin / metabolism
Stroke Volume
Reg. No./Substance:
0/Catecholamines; 0/Nucleotides, Cyclic; EC

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