Document Detail

Left ventricular function and energy homeostasis in patients with type 1 diabetes with and without microvascular complications.
MedLine Citation:
PMID:  20926147     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was performed to assess left ventricular (LV) energy metabolism and function in patients with type 1 diabetes with or without overt microvascular complications.
METHODS: We performed cardiac Magnetic Resonance Imaging (MRI) and (31)P spectroscopy (MRS) in 24 patients with overt microvascular complications and in 15 carefully selected patients without complications in spite of a long duration of the disease (>20 years) and matched for anthropometric features. 31 healthy subjects served as a control group.
RESULTS: Systolic function was preserved in all study subjects. Patients with overt complications showed a higher LV wall mass/end diastolic volume ratio and altered parameters of diastolic function when compared to patients without complications and to controls. They were also characterized by lower PCr/ATP ratio (a recognized marker of energy metabolism). No effect of HbA1c was detected within groups.
CONCLUSIONS: In patients with type 1 diabetes 1) overt microvascular complications were associated with altered LV geometry, diastolic function and energy metabolism 2) in patients without complications and duration of disease >20 years no association with these alterations were found despite poor glycemic control. The features of this highly selected subgroup of patients demonstrated that long lasting chronic hyperglycemia per se is not sufficient to induce abnormality of cardiac energy metabolism and that additional yet to be identified (metabolic or genetic) factors must be important contributing factors.
Gianluca Perseghin; Guido Lattuada; Francesco De Cobelli; Antonio Esposito; Tamara Canu; Francesca Ragogna; Paola Maffi; Paola Scifo; Antonio Secchi; Alessandro Del Maschio; Livio Luzi
Related Documents :
7114607 - Spectrum of myocardial contusion.
6486027 - Congestive heart failure with normal systolic function.
7373857 - Non-invasive localization of the pre-excitation site in patients with the wolff-parkins...
21968007 - Triggers of asthma and copd: are they different?
2731027 - Reciprocal inhibition between forearm muscles in patients with writer's cramp and other...
165157 - Genital herpes: treatment with methylene blue and light exposure.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-05
Journal Detail:
Title:  International journal of cardiology     Volume:  154     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-09-13     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  111-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine Triphosphate / metabolism
Blood Glucose / metabolism
Diabetes Mellitus, Type 1 / metabolism*,  physiopathology*
Diabetic Angiopathies / diagnosis,  metabolism*,  physiopathology*
Diastole / physiology
Energy Metabolism / physiology*
Fatty Acids / blood
Homeostasis / physiology
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Microcirculation / physiology
Middle Aged
Phosphocreatine / metabolism
Systole / physiology
Ventricular Function, Left / physiology*
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids; 020IUV4N33/Phosphocreatine; 8L70Q75FXE/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Down-regulation of CREB-binding protein expression blocks thrombin-mediated endothelial activation b...
Next Document:  Human plasma complement C3 is independently associated with coronary heart disease, but only in heav...